Trilafon and Intervertebral disc protrusion - a phase IV clinical study of FDA data

Summary:

Intervertebral disc protrusion is reported as a side effect among people who take Trilafon (perphenazine), especially for people who are female, 50-59 old, also take Synthroid, and have Sleep disorder.

The phase IV clinical study analyzes which people have Intervertebral disc protrusion when taking Trilafon. It is created by eHealthMe based on reports of 1,404 people who have side effects when taking Trilafon from the FDA, and is updated regularly.

What is Trilafon?

Trilafon has active ingredients of perphenazine. It is often used in bipolar disorder. eHealthMe is studying from 1,448 Trilafon users. Check the latest studies of Trilafon.

What is Intervertebral disc protrusion?

Intervertebral disc protrusion (spinal disc protrusion) is found to be associated with 1,533 drugs and 1,306 conditions by eHealthMe. Check the latest studies of Intervertebral disc protrusion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,404 people reported to have side effects when taking Trilafon.
Among them, 17 people (1.21%) have Intervertebral disc protrusion.

Could Trilafon cause Intervertebral disc protrusion?

Among these 17 people:

What is the gender of people who have Intervertebral disc protrusion when taking Trilafon? *

female: 94.12 %
male: 5.88 %

What is the age of people who have Intervertebral disc protrusion when taking Trilafon? *

What are other drugs people take besides Trilafon? *

What are other side effects people have besides Intervertebral disc protrusion? *

Intervertebral Disc Disorder (spinal disc disorder): 14 people, 82.35%
Mastication Disorder (disease of chewing food): 14 people, 82.35%
Hyperlipidaemia (presence of excess lipids in the blood): 14 people, 82.35%
Pain In Extremity: 14 people, 82.35%
Pain: 14 people, 82.35%
Osteosclerosis (an elevation in bone density): 14 people, 82.35%
Disability: 14 people, 82.35%
Neuroma (tumour of nerve tissue): 14 people, 82.35%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 14 people, 82.35%
Exostosis (formation of new bone on the surface of a bone): 14 people, 82.35%

What are the existing conditions these people have? *

Sleep Disorder: 2 people, 11.76%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.88%
Post-Traumatic Stress Disorder: 1 person, 5.88%
Depression: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Trilafon and have Intervertebral disc protrusion?

- Check whether Intervertebral disc protrusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trilafon:

Trilafon (1,448 reports)

Browse all side effects of Trilafon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,533 drugs)

Browse all the conditions that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,306 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on perphenazine (the active ingredients of Trilafon) and Trilafon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.