Trileptal and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Trileptal (oxcarbazepine), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lamictal, and have Convulsion.

The phase IV clinical study analyzes which people have Hepatic failure when taking Trileptal. It is created by eHealthMe based on reports of 22,012 people who have side effects when taking Trileptal from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,539 drugs and 1,894 conditions by eHealthMe. Check the latest studies of Hepatic failure.

On Aug, 04, 2026

22,012 people reported to have side effects when taking Trileptal.
Among them, 53 people (0.24%) have Hepatic failure.

Among these 53 people:

How long have people been on Trileptal when they have Hepatic failure? *

What is the gender of people who have Hepatic failure when taking Trileptal? *

female: 50 %
male: 50 %

What is the age of people who have Hepatic failure when taking Trileptal? *

What are other drugs people take besides Trileptal? *

Lamictal: 16 people, 30.19%
Keppra: 15 people, 28.30%
Valium: 8 people, 15.09%
Topamax: 6 people, 11.32%
Piperacillin And Tazobactam: 5 people, 9.43%
Rocephin: 4 people, 7.55%
Simvastatin: 4 people, 7.55%
Onfi: 3 people, 5.66%
Glucotrol Xl: 3 people, 5.66%
Seroquel: 3 people, 5.66%

What are other side effects people have besides Hepatic failure? *

Fever: 16 people, 30.19%
Acute Kidney Failure: 14 people, 26.42%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 10 people, 18.87%
Erythema Multiforme (a type of hypersensitivity reaction): 9 people, 16.98%
Alanine Aminotransferase Increased: 6 people, 11.32%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 6 people, 11.32%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 6 people, 11.32%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 6 people, 11.32%
Nausea And Vomiting: 6 people, 11.32%
Aspartate Aminotransferase Increased: 5 people, 9.43%

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 9.43%
Affective Disorder (mental disorder): 3 people, 5.66%
Sleep Disorder: 2 people, 3.77%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 3.77%
Infection: 2 people, 3.77%
Insomnia (sleeplessness): 1 person, 1.89%
Cardiac Failure Congestive: 1 person, 1.89%
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly): 1 person, 1.89%
Depression: 1 person, 1.89%
Fatigue (feeling of tiredness): 1 person, 1.89%

* Approximation only. Some reports may have incomplete information.

Do you take Trileptal and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trileptal:

Trileptal (23,558 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

Browse all side effects of Trileptal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,539 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,894 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxcarbazepine (the active ingredients of Trileptal) and Trileptal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.