Trimethoprim and Leukoencephalopathy - a phase IV clinical study of FDA data

Summary:

Leukoencephalopathy is reported as a side effect among people who take Trimethoprim (trimethoprim), especially for people who are female, 60+ old, also take Amlodipine, and have Non-hodgkin's lymphoma.

The phase IV clinical study analyzes which people have Leukoencephalopathy when taking Trimethoprim. It is created by eHealthMe based on reports of 7,878 people who have side effects when taking Trimethoprim from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Leukoencephalopathy?

Leukoencephalopathy (disease of the white matter in the brain) is found to be associated with 380 drugs and 626 conditions by eHealthMe. Check the latest studies of Leukoencephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

7,878 people reported to have side effects when taking Trimethoprim.
Among them, 12 people (0.15%) have Leukoencephalopathy.

Could Trimethoprim cause Leukoencephalopathy?

Among these 12 people:

What is the gender of people who have Leukoencephalopathy when taking Trimethoprim? *

female: 100 %
male: 0.0 %

What is the age of people who have Leukoencephalopathy when taking Trimethoprim? *

What are other drugs people take besides Trimethoprim? *

What are other side effects people have besides Leukoencephalopathy? *

Movement - Uncoordinated: 10 people, 83.33%
Memory Loss: 10 people, 83.33%
Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech): 10 people, 83.33%
Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 7 people, 58.33%

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 12 people, 100.00%
Inflammation: 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Trimethoprim and have Leukoencephalopathy?

- Check whether Leukoencephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trimethoprim:

Trimethoprim (8,213 reports)

Browse all side effects of Trimethoprim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Leukoencephalopathy:

Leukoencephalopathy (380 drugs)

Browse all the conditions that are associated with Leukoencephalopathy:

Leukoencephalopathy (626 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trimethoprim (the active ingredients of Trimethoprim) and Trimethoprim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.