Trintellix and Bipolar disorder - a phase IV clinical study of FDA data

Summary:

Bipolar disorder is reported as a side effect among people who take Trintellix (vortioxetine hydrobromide), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Bipolar disorder when taking Trintellix. It is created by eHealthMe based on reports of 12,454 people who have side effects when taking Trintellix from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Bipolar disorder?

Bipolar disorder (mood disorder) is found to be associated with 913 drugs and 1,231 conditions by eHealthMe. Check the latest studies of Bipolar disorder.

On Jul, 17, 2026

12,454 people reported to have side effects when taking Trintellix.
Among them, 46 people (0.37%) have Bipolar disorder.

Could Trintellix cause Bipolar disorder?

Among these 46 people:

How long have people been on Trintellix when they have Bipolar disorder? *

What is the gender of people who have Bipolar disorder when taking Trintellix? *

female: 76.09 %
male: 23.91 %

What is the age of people who have Bipolar disorder when taking Trintellix? *

What are other drugs people take besides Trintellix? *

What are other side effects people have besides Bipolar disorder? *

Stress And Anxiety: 17 people, 36.96%
Tremor (trembling or shaking movements in one or more parts of your body): 13 people, 28.26%
Feeling Drunk: 9 people, 19.57%
Suicidal Ideation: 8 people, 17.39%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 7 people, 15.22%
Weight Increased: 7 people, 15.22%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 15.22%
Panic Disorder: 7 people, 15.22%
Delirium (wild excitement): 7 people, 15.22%
Therapeutic Response Decreased (less preventive response): 7 people, 15.22%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 39.13%
Stress And Anxiety: 6 people, 13.04%
Pain: 4 people, 8.70%
Sleep Disorder: 3 people, 6.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 6.52%
Mood Swings (an extreme or rapid change in mood): 3 people, 6.52%
Indigestion: 2 people, 4.35%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 4.35%
High Blood Pressure: 2 people, 4.35%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Trintellix and have Bipolar disorder?

- Check whether Bipolar disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trintellix:

Trintellix (13,067 reports)

Bipolar disorder treatments and more:

Bipolar disorder (109,428 reports)

Browse all side effects of Trintellix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar disorder:

Bipolar disorder (913 drugs)

Browse all the conditions that are associated with Bipolar disorder:

Bipolar disorder (1,231 conditions)

Related publications that referenced our studies

Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on vortioxetine hydrobromide (the active ingredients of Trintellix) and Trintellix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.