Triphasil-21 and Migraine aggravated - a phase IV clinical study of FDA data

Summary:

Migraine aggravated is reported as a side effect among people who take Triphasil-21 (ethinyl estradiol; levonorgestrel), especially for people who are female, 30-39 old, have been taking the drug for 2 - 5 years also take Floxin Otic, and have Eczema.

The phase IV clinical study analyzes which people have Migraine aggravated when taking Triphasil-21. It is created by eHealthMe based on reports of 530 people who have side effects when taking Triphasil-21 from the FDA, and is updated regularly.

What is Triphasil-21?

Triphasil-21 has active ingredients of ethinyl estradiol; levonorgestrel. eHealthMe is studying from 534 Triphasil-21 users. Check the latest studies of Triphasil-21.

What is Migraine aggravated?

Migraine aggravated (headache) is found to be associated with 1,609 drugs and 482 conditions by eHealthMe. Check the latest studies of Migraine aggravated.

On Jul, 09, 2026

530 people reported to have side effects when taking Triphasil-21.
Among them, 16 people (3.02%) have Migraine aggravated.

Could Triphasil-21 cause Migraine aggravated?

Among these 16 people:

How long have people been on Triphasil-21 when they have Migraine aggravated? *

What is the gender of people who have Migraine aggravated when taking Triphasil-21? *

female: 100 %
male: 0.0 %

What is the age of people who have Migraine aggravated when taking Triphasil-21? *

What are other drugs people take besides Triphasil-21? *

Acetaminophen: 6 people, 37.50%
Desowen: 6 people, 37.50%
Morphine: 6 people, 37.50%
Zolpidem: 6 people, 37.50%
Ketorolac Tromethamine: 6 people, 37.50%
Naloxone: 6 people, 37.50%
Ketoconazole: 6 people, 37.50%
Ibuprofen: 6 people, 37.50%
Nizoral: 6 people, 37.50%
Floxin Otic: 6 people, 37.50%

What are other side effects people have besides Migraine aggravated? *

Weight Decreased: 8 people, 50.00%
Bone Pain: 7 people, 43.75%
Fatigue (feeling of tiredness): 7 people, 43.75%
Heart Attack: 6 people, 37.50%
Neuropathy Peripheral (surface nerve damage): 6 people, 37.50%
Muscle Aches (muscle pain): 6 people, 37.50%
Memory Loss: 6 people, 37.50%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 6 people, 37.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 37.50%
Weakness: 6 people, 37.50%

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 37.50%
Birth Control: 4 people, 25.00%
Osteoporosis (bones weak and more likely to break): 1 person, 6.25%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 6.25%
Muscle Spasms (muscle contraction): 1 person, 6.25%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.25%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
Headache (pain in head): 1 person, 6.25%
Depression: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Triphasil-21 and have Migraine aggravated?

- Check whether Migraine aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Triphasil-21:

Triphasil-21 (534 reports)

Migraine aggravated treatments and more:

Migraine aggravated (462 reports)

How severe was Migraine aggravated and when was it recovered:

Migraine aggravated in Triphasil-21

Expand to all the drugs that have ingredients of ethinyl estradiol; levonorgestrel:

Migraine aggravated and drugs with ingredients of ethinyl estradiol; levonorgestrel (316 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Triphasil-21:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Migraine aggravated:

Migraine aggravated (1,609 drugs)

Browse all the conditions that are associated with Migraine aggravated:

Migraine aggravated (482 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; levonorgestrel (the active ingredients of Triphasil-21) and Triphasil-21 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.