Triphasil-21 and Vaginal bleeding between periods - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding between periods is reported as a side effect among people who take Triphasil-21 (ethinyl estradiol; levonorgestrel), especially for people who are 20-29 old, have been taking the drug for 2 - 5 years also take Micronor, and have Birth control.

The phase IV clinical study analyzes which people have Vaginal bleeding between periods when taking Triphasil-21. It is created by eHealthMe based on reports of 530 people who have side effects when taking Triphasil-21 from the FDA, and is updated regularly.

What is Triphasil-21?

Triphasil-21 has active ingredients of ethinyl estradiol; levonorgestrel. eHealthMe is studying from 534 Triphasil-21 users. Check the latest studies of Triphasil-21.

What is Vaginal bleeding between periods?

Vaginal bleeding between periods is found to be associated with 577 drugs and 1,466 conditions by eHealthMe. Check the latest studies of Vaginal bleeding between periods.

On Jul, 13, 2026

530 people reported to have side effects when taking Triphasil-21.
Among them, 24 people (4.53%) have Vaginal bleeding between periods.

Could Triphasil-21 cause Vaginal bleeding between periods?

Among these 24 people:

How long have people been on Triphasil-21 when they have Vaginal bleeding between periods? *

What is the age of people who have Vaginal bleeding between periods when taking Triphasil-21? *

What are other drugs people take besides Triphasil-21? *

What are other side effects people have besides Vaginal bleeding between periods? *

Abdominal Distension: 2 people, 8.33%
Back Pain: 2 people, 8.33%
Nausea (feeling of having an urge to vomit): 2 people, 8.33%
Menstruation Irregular: 2 people, 8.33%
Gastroenteritis (inflammation of stomach and intestine): 1 person, 4.17%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 1 person, 4.17%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 1 person, 4.17%
Bradycardia (abnormally slow heart action): 1 person, 4.17%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 1 person, 4.17%
Clostridium Colitis (inflammation of colon by clostridium difficile bacteria infection): 1 person, 4.17%

What are the existing conditions these people have? *

Rashes (redness): 1 person, 4.17%
Itching: 1 person, 4.17%
Genital Discharge: 1 person, 4.17%
Birth Control: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Triphasil-21 and have Vaginal bleeding between periods?

- Check whether Vaginal bleeding between periods is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Triphasil-21:

Triphasil-21 (534 reports)

Vaginal bleeding between periods treatments and more:

Vaginal bleeding between periods (26,954 reports)

How severe was Vaginal bleeding between periods and when was it recovered:

Vaginal bleeding between periods in Triphasil-21

Expand to all the drugs that have ingredients of ethinyl estradiol; levonorgestrel:

Vaginal bleeding between periods and drugs with ingredients of ethinyl estradiol; levonorgestrel (904 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Triphasil-21:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (577 drugs)

Browse all the conditions that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (1,466 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; levonorgestrel (the active ingredients of Triphasil-21) and Triphasil-21 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.