Trulance and Weight decreased - a phase IV clinical study of FDA data

Summary:

Weight decreased is reported as a side effect among people who take Trulance (plecanatide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Constipation.

The phase IV clinical study analyzes which people have Weight decreased when taking Trulance. It is created by eHealthMe based on reports of 1,724 people who have side effects when taking Trulance from the FDA, and is updated regularly.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

What is Weight decreased?

Weight decreased is found to be associated with 3,377 drugs and 4,759 conditions by eHealthMe. Check the latest studies of Weight decreased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

1,724 people reported to have side effects when taking Trulance.
Among them, 59 people (3.42%) have Weight decreased.

Among these 59 people:

How long have people been on Trulance when they have Weight decreased? *

What is the gender of people who have Weight decreased when taking Trulance? *

female: 76.47 %
male: 23.53 %

What is the age of people who have Weight decreased when taking Trulance? *

What are other drugs people take besides Trulance? *

Vitamin D3: 19 people, 32.20%
Acetaminophen: 18 people, 30.51%
Epinephrine: 18 people, 30.51%
Topamax: 15 people, 25.42%
Heparin: 12 people, 20.34%
Aspirin: 11 people, 18.64%
Meloxicam: 11 people, 18.64%
Miralax: 11 people, 18.64%
Budesonide: 10 people, 16.95%
Diphenhydramine Hydrochloride: 10 people, 16.95%

What are other side effects people have besides Weight decreased? *

Diarrhea: 17 people, 28.81%
Cellulitis (infection under the skin): 12 people, 20.34%
Sinusitis (inflammation of sinus): 12 people, 20.34%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 16.95%
Weakness: 9 people, 15.25%
Fall: 9 people, 15.25%
Rashes (redness): 9 people, 15.25%
Fungal Infection: 8 people, 13.56%
Dizziness: 8 people, 13.56%
Blood Calcium Abnormal: 8 people, 13.56%

What are the existing conditions these people have? *

Constipation: 13 people, 22.03%
Irritable Bowel Syndrome: 8 people, 13.56%
Immunodeficiency Common Variable: 8 people, 13.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.78%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.78%
Drowsiness: 4 people, 6.78%
Primary Immunodeficiency Syndrome: 3 people, 5.08%
High Blood Pressure: 2 people, 3.39%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 3.39%
Breakthrough Pain: 1 person, 1.69%

* Approximation only. Some reports may have incomplete information.

Do you take Trulance and have Weight decreased?

- Check whether Weight decreased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trulance:

Trulance (1,746 reports)

Weight decreased treatments and more:

Weight decreased (364,522 reports)

Browse all side effects of Trulance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight decreased:

Weight decreased (3,377 drugs)

Browse all the conditions that are associated with Weight decreased:

Weight decreased (4,759 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on plecanatide (the active ingredients of Trulance) and Trulance (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.