Truvada and Bipolar disorder - a phase IV clinical study of FDA data

Summary:

Bipolar disorder is reported as a side effect among people who take Truvada (emtricitabine; tenofovir disoproxil fumarate), especially for people who are male, 40-49 old, have been taking the drug for 5 - 10 years also take Norvir, and have High blood pressure.

The phase IV clinical study analyzes which people have Bipolar disorder when taking Truvada. It is created by eHealthMe based on reports of 75,548 people who have side effects when taking Truvada from the FDA, and is updated regularly.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

What is Bipolar disorder?

Bipolar disorder (mood disorder) is found to be associated with 913 drugs and 1,231 conditions by eHealthMe. Check the latest studies of Bipolar disorder.

On Jul, 16, 2026

75,548 people reported to have side effects when taking Truvada.
Among them, 54 people (0.07%) have Bipolar disorder.

Among these 54 people:

How long have people been on Truvada when they have Bipolar disorder? *

What is the gender of people who have Bipolar disorder when taking Truvada? *

female: 32.08 %
male: 67.92 %

What is the age of people who have Bipolar disorder when taking Truvada? *

What are other drugs people take besides Truvada? *

What are other side effects people have besides Bipolar disorder? *

Pain: 29 people, 53.70%
Emotional Distress: 28 people, 51.85%
Stress And Anxiety: 26 people, 48.15%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 26 people, 48.15%
Depression: 24 people, 44.44%
Osteoporosis (bones weak and more likely to break): 21 people, 38.89%
Chronic Kidney Disease: 13 people, 24.07%
Bone Density Decreased: 12 people, 22.22%
Suicidal Ideation: 10 people, 18.52%
Multiple Fractures: 9 people, 16.67%

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 9.26%
Gastroenteritis (inflammation of stomach and intestine): 4 people, 7.41%
Mycobacterium Avium Complex Infection: 4 people, 7.41%
Gastritis (inflammation of stomach): 3 people, 5.56%
Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 3 people, 5.56%
Neuropathy Peripheral (surface nerve damage): 3 people, 5.56%
Anaemia (lack of blood): 2 people, 3.70%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 3.70%
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium): 2 people, 3.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Truvada and have Bipolar disorder?

- Check whether Bipolar disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Truvada:

Truvada (76,246 reports)

Bipolar disorder treatments and more:

Bipolar disorder (109,428 reports)

How severe was Bipolar disorder and when was it recovered:

Bipolar disorder in Truvada

Expand to all the drugs that have ingredients of emtricitabine; tenofovir disoproxil fumarate:

Bipolar disorder and drugs with ingredients of emtricitabine; tenofovir disoproxil fumarate (44 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Truvada:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar disorder:

Bipolar disorder (913 drugs)

Browse all the conditions that are associated with Bipolar disorder:

Bipolar disorder (1,231 conditions)

Related publications that referenced our studies

Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on emtricitabine; tenofovir disoproxil fumarate (the active ingredients of Truvada) and Truvada (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.