Tussionex pennkinetic and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Tussionex pennkinetic (chlorpheniramine polistirex; hydrocodone polistirex), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Lasix, and have Pain.

The phase IV clinical study analyzes which people have Depression when taking Tussionex pennkinetic. It is created by eHealthMe based on reports of 782 people who have side effects when taking Tussionex pennkinetic from the FDA, and is updated regularly.

What is Tussionex pennkinetic?

Tussionex pennkinetic has active ingredients of chlorpheniramine polistirex; hydrocodone polistirex. It is often used in cough. eHealthMe is studying from 963 Tussionex pennkinetic users. Check the latest studies of Tussionex pennkinetic.

What is Depression?

Depression is found to be associated with 3,168 drugs and 4,130 conditions by eHealthMe. Check the latest studies of Depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

782 people reported to have side effects when taking Tussionex pennkinetic.
Among them, 23 people (2.94%) have Depression.

Could Tussionex pennkinetic cause Depression?

Among these 23 people:

How long have people been on Tussionex pennkinetic when they have Depression? *

What is the gender of people who have Depression when taking Tussionex pennkinetic? *

female: 56.52 %
male: 43.48 %

What is the age of people who have Depression when taking Tussionex pennkinetic? *

What are other drugs people take besides Tussionex pennkinetic? *

What are other side effects people have besides Depression? *

Stress And Anxiety: 14 people, 60.87%
Joint Pain: 9 people, 39.13%
Pain: 9 people, 39.13%
Headache (pain in head): 7 people, 30.43%
Muscle Spasms (muscle contraction): 7 people, 30.43%
Fatigue (feeling of tiredness): 7 people, 30.43%
Weakness: 6 people, 26.09%
High Blood Pressure: 6 people, 26.09%
Back Pain: 6 people, 26.09%
Pain In Extremity: 6 people, 26.09%

What are the existing conditions these people have? *

Blood Pressure Abnormal: 6 people, 26.09%
Pain: 6 people, 26.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 17.39%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 4 people, 17.39%
Diabetes: 4 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 17.39%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 17.39%
Bone Disorder: 4 people, 17.39%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 17.39%
Urine Output - Decreased: 4 people, 17.39%

* Approximation only. Some reports may have incomplete information.

Do you take Tussionex pennkinetic and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tussionex pennkinetic:

Tussionex pennkinetic (963 reports)

Depression treatments and more:

Depression (652,162 reports)

How severe was Depression and when was it recovered:

Depression in Tussionex pennkinetic

Expand to all the drugs that have ingredients of chlorpheniramine polistirex; hydrocodone polistirex:

Depression and drugs with ingredients of chlorpheniramine polistirex; hydrocodone polistirex

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tussionex pennkinetic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,168 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,130 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on chlorpheniramine polistirex; hydrocodone polistirex (the active ingredients of Tussionex pennkinetic) and Tussionex pennkinetic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.