Twynsta and Hypotension - a phase IV clinical study of FDA data

Summary:

Hypotension is reported as a side effect among people who take Twynsta (amlodipine besylate; telmisartan), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Apixaban, and have Prostate cancer.

The phase IV clinical study analyzes which people have Hypotension when taking Twynsta. It is created by eHealthMe based on reports of 1,017 people who have side effects when taking Twynsta from the FDA, and is updated regularly.

What is Twynsta?

Twynsta has active ingredients of amlodipine besylate; telmisartan. It is often used in high blood pressure. eHealthMe is studying from 1,063 Twynsta users. Check the latest studies of Twynsta.

What is Hypotension?

Hypotension (abnormally low blood pressure) is found to be associated with 3,353 drugs and 4,763 conditions by eHealthMe. Check the latest studies of Hypotension.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

1,017 people reported to have side effects when taking Twynsta.
Among them, 27 people (2.65%) have Hypotension.

Among these 27 people:

How long have people been on Twynsta when they have Hypotension? *

What is the gender of people who have Hypotension when taking Twynsta? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Hypotension when taking Twynsta? *

What are other drugs people take besides Twynsta? *

Apixaban: 5 people, 18.52%
Irinotecan Hydrochloride: 4 people, 14.81%
Oxaliplatin: 4 people, 14.81%
Xanax: 4 people, 14.81%
Levothyroxine Sodium: 4 people, 14.81%
Venlafaxine Hydrochloride: 4 people, 14.81%
Aspirin: 4 people, 14.81%
Firmagon: 4 people, 14.81%
Ezetimibe: 4 people, 14.81%
Emend: 4 people, 14.81%

What are other side effects people have besides Hypotension? *

Fatigue (feeling of tiredness): 13 people, 48.15%
Fever: 9 people, 33.33%
Nausea (feeling of having an urge to vomit): 9 people, 33.33%
Weakness: 8 people, 29.63%
Dyspnea (difficult or laboured breathing): 8 people, 29.63%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 18.52%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 5 people, 18.52%
Hot Flush (sudden feelings of heat): 5 people, 18.52%
Dizziness: 5 people, 18.52%
Feeling Hot: 5 people, 18.52%

What are the existing conditions these people have? *

High Blood Cholesterol: 5 people, 18.52%
Prostate Cancer: 5 people, 18.52%
Depression: 4 people, 14.81%
Adenocarcinoma Pancreas (cancer of pancreas): 4 people, 14.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.41%
Osteoporosis (bones weak and more likely to break): 2 people, 7.41%
Gout (uric acid crystals building up in the body): 2 people, 7.41%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.41%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 7.41%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Twynsta and have Hypotension?

- Check whether Hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Twynsta:

Twynsta (1,063 reports)

Hypotension treatments and more:

Hypotension (329,856 reports)

How severe was Hypotension and when was it recovered:

Hypotension in Twynsta

Expand to all the drugs that have ingredients of amlodipine besylate; telmisartan:

Hypotension and drugs with ingredients of amlodipine besylate; telmisartan (618 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Twynsta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypotension:

Hypotension (3,353 drugs)

Browse all the conditions that are associated with Hypotension:

Hypotension (4,763 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; telmisartan (the active ingredients of Twynsta) and Twynsta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.