Tylenol w/ codeine no. 3 and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate), especially for people who are male, 60+ old, also take Prilosec, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Anhedonia when taking Tylenol w/ codeine no. 3. It is created by eHealthMe based on reports of 4,453 people who have side effects when taking Tylenol w/ codeine no. 3 from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,506 drugs and 1,284 conditions by eHealthMe. Check the latest studies of Anhedonia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

4,453 people reported to have side effects when taking Tylenol w/ codeine no. 3.
Among them, 34 people (0.76%) have Anhedonia.

Could Tylenol w/ codeine no. 3 cause Anhedonia?

Among these 34 people:

What is the gender of people who have Anhedonia when taking Tylenol w/ codeine no. 3? *

female: 47.06 %
male: 52.94 %

What is the age of people who have Anhedonia when taking Tylenol w/ codeine no. 3? *

What are other drugs people take besides Tylenol w/ codeine no. 3? *

What are other side effects people have besides Anhedonia? *

Stress And Anxiety: 31 people, 91.18%
Injury: 27 people, 79.41%
Emotional Distress: 16 people, 47.06%
Weakness: 14 people, 41.18%
Fall: 13 people, 38.24%
Head Injury: 12 people, 35.29%
Intervertebral Disc Protrusion (spinal disc protrusion): 12 people, 35.29%
Neck Pain: 12 people, 35.29%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 12 people, 35.29%
Muscle Spasms (muscle contraction): 12 people, 35.29%

What are the existing conditions these people have? *

High Blood Cholesterol: 13 people, 38.24%
Multiple Myeloma (cancer of the plasma cells): 11 people, 32.35%
High Blood Pressure: 11 people, 32.35%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 32.35%
Stress And Anxiety: 4 people, 11.76%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 8.82%
Irritable Bowel Syndrome: 3 people, 8.82%
Sedation: 2 people, 5.88%
Nuclear Magnetic Resonance Imaging Brain: 2 people, 5.88%
Menstruation Irregular: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine no. 3 and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine no. 3:

Tylenol w/ codeine no. 3 (4,920 reports)

Anhedonia treatments and more:

Anhedonia (51,944 reports)

How severe was Anhedonia and when was it recovered:

Anhedonia in Tylenol w/ codeine no. 3

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Anhedonia and drugs with ingredients of acetaminophen; codeine phosphate (166 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine no. 3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,506 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,284 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine no. 3) and Tylenol w/ codeine no. 3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.