Tylenol w/ codeine no. 3 and Hypothyroidism - a phase IV clinical study of FDA data

Summary:

Hypothyroidism is reported as a side effect among people who take Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, also take Synthroid, and have Osteoarthritis.

The phase IV clinical study analyzes which people have Hypothyroidism when taking Tylenol w/ codeine no. 3. It is created by eHealthMe based on reports of 4,453 people who have side effects when taking Tylenol w/ codeine no. 3 from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

What is Hypothyroidism?

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,616 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.

On Apr, 27, 2026

4,453 people reported to have side effects when taking Tylenol w/ codeine no. 3.
Among them, 38 people (0.85%) have Hypothyroidism.

Could Tylenol w/ codeine no. 3 cause Hypothyroidism?

Among these 38 people:

What is the gender of people who have Hypothyroidism when taking Tylenol w/ codeine no. 3? *

female: 89.19 %
male: 10.81 %

What is the age of people who have Hypothyroidism when taking Tylenol w/ codeine no. 3? *

What are other drugs people take besides Tylenol w/ codeine no. 3? *

What are other side effects people have besides Hypothyroidism? *

Dizziness: 16 people, 42.11%
Nausea (feeling of having an urge to vomit): 14 people, 36.84%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 31.58%
Asthma: 12 people, 31.58%
Stress And Anxiety: 12 people, 31.58%
Weakness: 11 people, 28.95%
High Blood Pressure: 11 people, 28.95%
Chest Pain: 11 people, 28.95%
Joint Pain: 10 people, 26.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 26.32%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 7 people, 18.42%
Asthma: 7 people, 18.42%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 18.42%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 15.79%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.89%
Osteoporosis (bones weak and more likely to break): 3 people, 7.89%
Depression: 3 people, 7.89%
Metastases To Bone (cancer spreads to bone): 2 people, 5.26%
Joint Pain: 2 people, 5.26%
Breakthrough Pain: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine no. 3 and have Hypothyroidism?

- Check whether Hypothyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine no. 3:

Tylenol w/ codeine no. 3 (4,920 reports)

Hypothyroidism treatments and more:

Hypothyroidism (168,065 reports)

How severe was Hypothyroidism and when was it recovered:

Hypothyroidism in Tylenol w/ codeine no. 3

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Hypothyroidism and drugs with ingredients of acetaminophen; codeine phosphate (204 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine no. 3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypothyroidism:

Hypothyroidism (1,616 drugs)

Browse all the conditions that are associated with Hypothyroidism:

Hypothyroidism (2,600 conditions)

Related publications that referenced our studies

Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .
Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine no. 3) and Tylenol w/ codeine no. 3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.