Tylenol w/ codeine no. 4 and Depression aggravated - a phase IV clinical study of FDA data

Summary:

Depression aggravated is reported as a side effect among people who take Tylenol w/ codeine no. 4 (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, also take Elavil, and have Quit smoking.

The phase IV clinical study analyzes which people have Depression aggravated when taking Tylenol w/ codeine no. 4. It is created by eHealthMe based on reports of 401 people who have side effects when taking Tylenol w/ codeine no. 4 from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 4?

Tylenol w/ codeine no. 4 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 460 Tylenol w/ codeine no. 4 users. Check the latest studies of Tylenol w/ codeine no. 4.

What is Depression aggravated?

Depression aggravated is found to be associated with 2,374 drugs and 748 conditions by eHealthMe. Check the latest studies of Depression aggravated.

On Jul, 18, 2026

401 people reported to have side effects when taking Tylenol w/ codeine no. 4.
Among them, 23 people (5.74%) have Depression aggravated.

Could Tylenol w/ codeine no. 4 cause Depression aggravated?

Among these 23 people:

What is the gender of people who have Depression aggravated when taking Tylenol w/ codeine no. 4? *

female: 56.52 %
male: 43.48 %

What is the age of people who have Depression aggravated when taking Tylenol w/ codeine no. 4? *

What are other drugs people take besides Tylenol w/ codeine no. 4? *

What are other side effects people have besides Depression aggravated? *

Stress And Anxiety: 14 people, 60.87%
Homicidal Ideation (thoughts about human killing another human): 12 people, 52.17%
Self-Injurious Ideation: 12 people, 52.17%
Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 12 people, 52.17%
Abnormal Behavior: 11 people, 47.83%
Nervousness: 8 people, 34.78%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 17.39%
Fall: 4 people, 17.39%
Nausea And Vomiting: 3 people, 13.04%
Nausea (feeling of having an urge to vomit): 3 people, 13.04%

What are the existing conditions these people have? *

Stress And Anxiety: 12 people, 52.17%
Quit Smoking: 12 people, 52.17%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 6 people, 26.09%
Abdominal Discomfort: 6 people, 26.09%
Gastric Disorder (disease of stomach): 4 people, 17.39%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.35%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 4.35%
High Blood Pressure: 1 person, 4.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.35%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine no. 4 and have Depression aggravated?

- Check whether Depression aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine no. 4:

Tylenol w/ codeine no. 4 (460 reports)

Depression aggravated treatments and more:

Depression aggravated (2,253 reports)

How severe was Depression aggravated and when was it recovered:

Depression aggravated in Tylenol w/ codeine no. 4

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Depression aggravated and drugs with ingredients of acetaminophen; codeine phosphate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine no. 4:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression aggravated:

Depression aggravated (2,374 drugs)

Browse all the conditions that are associated with Depression aggravated:

Depression aggravated (748 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine no. 4) and Tylenol w/ codeine no. 4 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.