Tylenol w/ codeine and Injection site erythema - a phase IV clinical study of FDA data

Summary:

Injection site erythema is reported as a side effect among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Injection site erythema when taking Tylenol w/ codeine. It is created by eHealthMe based on reports of 7,307 people who have side effects when taking Tylenol w/ codeine from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Injection site erythema?

Injection site erythema (redness at injection site) is found to be associated with 1,452 drugs and 1,417 conditions by eHealthMe. Check the latest studies of Injection site erythema.

On Aug, 11, 2026

7,307 people reported to have side effects when taking Tylenol w/ codeine.
Among them, 31 people (0.42%) have Injection site erythema.

Could Tylenol w/ codeine cause Injection site erythema?

Among these 31 people:

What is the gender of people who have Injection site erythema when taking Tylenol w/ codeine? *

female: 100 %
male: 0.0 %

What is the age of people who have Injection site erythema when taking Tylenol w/ codeine? *

What are other drugs people take besides Tylenol w/ codeine? *

What are other side effects people have besides Injection site erythema? *

Injection Site Pruritus (severe itching at injection site): 8 people, 25.81%
Head Injury: 8 people, 25.81%
Fatigue (feeling of tiredness): 7 people, 22.58%
Injection Site Haematoma (localized swelling filled with blood at injection site): 7 people, 22.58%
Headache (pain in head): 7 people, 22.58%
Nausea (feeling of having an urge to vomit): 7 people, 22.58%
Weakness: 7 people, 22.58%
Injection Site Reaction: 6 people, 19.35%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 19.35%
Injection Site Pain: 6 people, 19.35%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 29.03%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 16.13%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 12.90%
High Blood Pressure: 3 people, 9.68%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 9.68%
Hepatitis C: 3 people, 9.68%
Hypersensitivity: 2 people, 6.45%
Type 2 Diabetes: 2 people, 6.45%
High Blood Cholesterol: 2 people, 6.45%
Migraine (headache): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine and have Injection site erythema?

- Check whether Injection site erythema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine:

Tylenol w/ codeine (8,107 reports)

Injection site erythema treatments and more:

Injection site erythema (120,311 reports)

How severe was Injection site erythema and when was it recovered:

Injection site erythema in Tylenol w/ codeine

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Injection site erythema and drugs with ingredients of acetaminophen; codeine phosphate (85 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site erythema:

Injection site erythema (1,452 drugs)

Browse all the conditions that are associated with Injection site erythema:

Injection site erythema (1,417 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine) and Tylenol w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.