Tylenol w/ codeine and Nephrogenic systemic fibrosis - a phase IV clinical study of FDA data

Summary:

Nephrogenic systemic fibrosis is reported as a side effect among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate), especially for people who are female, 50-59 old, also take Magnevist, and have Nuclear magnetic resonance imaging brain.

The phase IV clinical study analyzes which people have Nephrogenic systemic fibrosis when taking Tylenol w/ codeine. It is created by eHealthMe based on reports of 7,307 people who have side effects when taking Tylenol w/ codeine from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Nephrogenic systemic fibrosis?

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease) is found to be associated with 511 drugs and 671 conditions by eHealthMe. Check the latest studies of Nephrogenic systemic fibrosis.

On Jul, 04, 2026

7,307 people reported to have side effects when taking Tylenol w/ codeine.
Among them, 44 people (0.6%) have Nephrogenic systemic fibrosis.

Could Tylenol w/ codeine cause Nephrogenic systemic fibrosis?

Among these 44 people:

What is the gender of people who have Nephrogenic systemic fibrosis when taking Tylenol w/ codeine? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Nephrogenic systemic fibrosis when taking Tylenol w/ codeine? *

What are other drugs people take besides Tylenol w/ codeine? *

What are other side effects people have besides Nephrogenic systemic fibrosis? *

Mobility Decreased (ability to move is reduced): 32 people, 72.73%
Skin Fibrosis (fibrous tissue formation on skin): 27 people, 61.36%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 27 people, 61.36%
Oedema Peripheral (superficial swelling): 26 people, 59.09%
Skin Hypertrophy (skin cells enlarges): 25 people, 56.82%
Skin Induration (an abnormally hard spot or area on the skin): 25 people, 56.82%
Skin Hyperpigmentation (disorders affect the colour of your skin): 24 people, 54.55%
Rashes (redness): 24 people, 54.55%
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 23 people, 52.27%
Skin Tightness: 23 people, 52.27%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 20 people, 45.45%
Stress And Anxiety: 14 people, 31.82%
Itching: 14 people, 31.82%
High Blood Cholesterol: 13 people, 29.55%
Nausea (feeling of having an urge to vomit): 12 people, 27.27%
Depression: 12 people, 27.27%
Device Related Infection: 12 people, 27.27%
Herpes Zoster: 12 people, 27.27%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 12 people, 27.27%
Nuclear Magnetic Resonance Imaging Abdominal: 10 people, 22.73%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine and have Nephrogenic systemic fibrosis?

- Check whether Nephrogenic systemic fibrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine:

Tylenol w/ codeine (8,107 reports)

Nephrogenic systemic fibrosis treatments and more:

Nephrogenic systemic fibrosis (6,191 reports)

How severe was Nephrogenic systemic fibrosis and when was it recovered:

Nephrogenic systemic fibrosis in Tylenol w/ codeine

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Nephrogenic systemic fibrosis and drugs with ingredients of acetaminophen; codeine phosphate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephrogenic systemic fibrosis:

Nephrogenic systemic fibrosis (511 drugs)

Browse all the conditions that are associated with Nephrogenic systemic fibrosis:

Nephrogenic systemic fibrosis (671 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine) and Tylenol w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.