Tylenol w/ codeine and Serotonin syndrome - a phase IV clinical study of FDA data

Summary:

Serotonin syndrome is reported as a side effect among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate), especially for people who are female, 20-29 old, also take Zithromax, and have Depression.

The phase IV clinical study analyzes which people have Serotonin syndrome when taking Tylenol w/ codeine. It is created by eHealthMe based on reports of 7,307 people who have side effects when taking Tylenol w/ codeine from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Serotonin syndrome?

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) is found to be associated with 714 drugs and 1,200 conditions by eHealthMe. Check the latest studies of Serotonin syndrome.

On Jul, 25, 2026

7,307 people reported to have side effects when taking Tylenol w/ codeine.
Among them, 11 people (0.15%) have Serotonin syndrome.

Could Tylenol w/ codeine cause Serotonin syndrome?

Among these 11 people:

What is the gender of people who have Serotonin syndrome when taking Tylenol w/ codeine? *

female: 90 %
male: 10 %

What is the age of people who have Serotonin syndrome when taking Tylenol w/ codeine? *

What are other drugs people take besides Tylenol w/ codeine? *

What are other side effects people have besides Serotonin syndrome? *

Memory Loss: 5 people, 45.45%
Chest Pain: 5 people, 45.45%
Diarrhea: 5 people, 45.45%
Urination - Painful: 5 people, 45.45%
Nausea (feeling of having an urge to vomit): 4 people, 36.36%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 36.36%
Insomnia (sleeplessness): 4 people, 36.36%
Dysphemia (stammering or stuttering): 4 people, 36.36%
Depression: 4 people, 36.36%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 36.36%

What are the existing conditions these people have? *

Depression: 4 people, 36.36%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
Rashes (redness): 2 people, 18.18%
Migraine (headache): 1 person, 9.09%
Headache (pain in head): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine and have Serotonin syndrome?

- Check whether Serotonin syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine:

Tylenol w/ codeine (8,107 reports)

Serotonin syndrome treatments and more:

Serotonin syndrome (20,564 reports)

How severe was Serotonin syndrome and when was it recovered:

Serotonin syndrome in Tylenol w/ codeine

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Serotonin syndrome and drugs with ingredients of acetaminophen; codeine phosphate (159 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Serotonin syndrome:

Serotonin syndrome (714 drugs)

Browse all the conditions that are associated with Serotonin syndrome:

Serotonin syndrome (1,200 conditions)

Related publications that referenced our studies

Behnoush B, Memarian A, Teimoory M, "Naltrexone Induced Serotonin Syndrome", International Journal of Medical Toxicology and Forensic Medicine, 2013 Apr .
Behnoush B, Memarian A, Teimoory M, "Naltrexone Induced Serotonin Syndrome", International Journal of Medical Toxicology and Forensic Medicine, 2013 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine) and Tylenol w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.