Tylenol w/ codeine and Synovitis - a phase IV clinical study of FDA data

Summary:

Synovitis is reported as a side effect among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, also take Peridex, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Synovitis when taking Tylenol w/ codeine. It is created by eHealthMe based on reports of 7,307 people who have side effects when taking Tylenol w/ codeine from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Synovitis?

Synovitis (inflammation of the synovial membrane) is found to be associated with 694 drugs and 508 conditions by eHealthMe. Check the latest studies of Synovitis.

On Jul, 06, 2026

7,307 people reported to have side effects when taking Tylenol w/ codeine.
Among them, 15 people (0.21%) have Synovitis.

Could Tylenol w/ codeine cause Synovitis?

Among these 15 people:

What is the gender of people who have Synovitis when taking Tylenol w/ codeine? *

female: 53.33 %
male: 46.67 %

What is the age of people who have Synovitis when taking Tylenol w/ codeine? *

What are other drugs people take besides Tylenol w/ codeine? *

What are other side effects people have besides Synovitis? *

Joint Pain: 12 people, 80.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 60.00%
Osteonecrosis Of Jaw (death of bone of jaw): 8 people, 53.33%
Stress And Anxiety: 8 people, 53.33%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 8 people, 53.33%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 8 people, 53.33%
Bone Disorder: 8 people, 53.33%
Pain In Jaw: 8 people, 53.33%
Intervertebral Disc Degeneration (spinal disc degeneration): 8 people, 53.33%
Injury: 8 people, 53.33%

What are the existing conditions these people have? *

Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 4 people, 26.67%
Multiple Myeloma (cancer of the plasma cells): 4 people, 26.67%
High Blood Pressure: 4 people, 26.67%
High Blood Cholesterol: 4 people, 26.67%
Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 26.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 26.67%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 20.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 20.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 13.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine and have Synovitis?

- Check whether Synovitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine:

Tylenol w/ codeine (8,107 reports)

Synovitis treatments and more:

Synovitis (24,130 reports)

How severe was Synovitis and when was it recovered:

Synovitis in Tylenol w/ codeine

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Synovitis and drugs with ingredients of acetaminophen; codeine phosphate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Synovitis:

Synovitis (694 drugs)

Browse all the conditions that are associated with Synovitis:

Synovitis (508 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine) and Tylenol w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.