Tylenol and Polymyositis - a phase IV clinical study of FDA data

Summary:

Polymyositis is reported as a side effect among people who take Tylenol (acetaminophen), especially for people who are female, 60+ old, also take Pantoprazole, and have Polycythaemia vera.

The phase IV clinical study analyzes which people have Polymyositis when taking Tylenol. It is created by eHealthMe based on reports of 217,809 people who have side effects when taking Tylenol from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Polymyositis?

Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles) is found to be associated with 247 drugs and 434 conditions by eHealthMe. Check the latest studies of Polymyositis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

217,809 people reported to have side effects when taking Tylenol.
Among them, 40 people (0.02%) have Polymyositis.

Among these 40 people:

What is the gender of people who have Polymyositis when taking Tylenol? *

female: 77.42 %
male: 22.58 %

What is the age of people who have Polymyositis when taking Tylenol? *

What are other drugs people take besides Tylenol? *

What are other side effects people have besides Polymyositis? *

Weakness: 30 people, 75.00%
Urinary Tract Infection: 23 people, 57.50%
Diarrhea: 20 people, 50.00%
Balance Disorder: 19 people, 47.50%
Oxygen Saturation Decreased: 18 people, 45.00%
Coronary Artery Occlusion (complete obstruction of blood flow in a coronary artery): 18 people, 45.00%
Heart Attack: 18 people, 45.00%
Pneumonia: 18 people, 45.00%
The Flu (the flu is caused by an influenza virus): 18 people, 45.00%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 18 people, 45.00%

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 8 people, 20.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 7 people, 17.50%
Muscle Disorder (muscle disease): 4 people, 10.00%
High Blood Cholesterol: 2 people, 5.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.50%
Prostate Cancer: 1 person, 2.50%
Osteoporosis (bones weak and more likely to break): 1 person, 2.50%
Immunodeficiency Common Variable: 1 person, 2.50%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 1 person, 2.50%
Hepatitis C: 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol and have Polymyositis?

- Check whether Polymyositis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol:

Tylenol (222,310 reports)

Polymyositis treatments and more:

Polymyositis (5,024 reports)

Browse all side effects of Tylenol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polymyositis:

Polymyositis (247 drugs)

Browse all the conditions that are associated with Polymyositis:

Polymyositis (434 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Tylenol) and Tylenol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.