Tylenol and Primary myelofibrosis - a phase IV clinical study of FDA data

Summary:

Primary myelofibrosis is reported as a side effect among people who take Tylenol (acetaminophen), especially for people who are male, 60+ old, also take Jakafi, and have Polycythaemia vera.

The phase IV clinical study analyzes which people have Primary myelofibrosis when taking Tylenol. It is created by eHealthMe based on reports of 217,809 people who have side effects when taking Tylenol from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Primary myelofibrosis?

Primary myelofibrosis (primary disorder of the bone marrow) is found to be associated with 320 drugs and 841 conditions by eHealthMe. Check the latest studies of Primary myelofibrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

217,809 people reported to have side effects when taking Tylenol.
Among them, 49 people (0.02%) have Primary myelofibrosis.

Could Tylenol cause Primary myelofibrosis?

Among these 49 people:

What is the gender of people who have Primary myelofibrosis when taking Tylenol? *

female: 50 %
male: 50 %

What is the age of people who have Primary myelofibrosis when taking Tylenol? *

What are other drugs people take besides Tylenol? *

What are other side effects people have besides Primary myelofibrosis? *

Fatigue (feeling of tiredness): 23 people, 46.94%
Weakness: 17 people, 34.69%
Haemoglobin Decreased: 17 people, 34.69%
Thrombocytopenia (decrease of platelets in blood): 16 people, 32.65%
Anaemia (lack of blood): 15 people, 30.61%
Splenomegaly (enlargement of spleen): 14 people, 28.57%
Diarrhea: 13 people, 26.53%
Weight Decreased: 13 people, 26.53%
Dyspnea (difficult or laboured breathing): 13 people, 26.53%
Head Injury: 12 people, 24.49%

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 8 people, 16.33%
Urination - Painful: 7 people, 14.29%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 7 people, 14.29%
Bladder Pain: 7 people, 14.29%
Corneal Disorder: 3 people, 6.12%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 3 people, 6.12%
Dry Eyes (lack of adequate tears): 3 people, 6.12%
Gastric Disorder (disease of stomach): 3 people, 6.12%
Oedema (fluid collection in tissue): 2 people, 4.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol and have Primary myelofibrosis?

- Check whether Primary myelofibrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol:

Tylenol (222,310 reports)

Browse all side effects of Tylenol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Primary myelofibrosis:

Primary myelofibrosis (320 drugs)

Browse all the conditions that are associated with Primary myelofibrosis:

Primary myelofibrosis (841 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Tylenol) and Tylenol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.