Tylenol and Skin hypopigmentation - a phase IV clinical study of FDA data

Summary:

Skin hypopigmentation is reported as a side effect among people who take Tylenol (acetaminophen), especially for people who are female, 60+ old, also take Prednisone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Skin hypopigmentation when taking Tylenol. It is created by eHealthMe based on reports of 217,809 people who have side effects when taking Tylenol from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Skin hypopigmentation?

Skin hypopigmentation (loss of skin colour) is found to be associated with 155 drugs and 286 conditions by eHealthMe. Check the latest studies of Skin hypopigmentation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

217,809 people reported to have side effects when taking Tylenol.
Among them, 30 people (0.01%) have Skin hypopigmentation.

Could Tylenol cause Skin hypopigmentation?

Among these 30 people:

What is the gender of people who have Skin hypopigmentation when taking Tylenol? *

female: 86.96 %
male: 13.04 %

What is the age of people who have Skin hypopigmentation when taking Tylenol? *

What are other drugs people take besides Tylenol? *

What are other side effects people have besides Skin hypopigmentation? *

Fatigue (feeling of tiredness): 20 people, 66.67%
Cough: 15 people, 50.00%
Back Pain: 12 people, 40.00%
Rashes (redness): 12 people, 40.00%
Nausea (feeling of having an urge to vomit): 9 people, 30.00%
Pain In Extremity: 9 people, 30.00%
Oedema Peripheral (superficial swelling): 9 people, 30.00%
High Blood Pressure: 9 people, 30.00%
Skin Discoloration: 9 people, 30.00%
Breath Sounds Abnormal: 8 people, 26.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 26.67%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 20.00%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 1 person, 3.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 3.33%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 1 person, 3.33%
Oedema (fluid collection in tissue): 1 person, 3.33%
Nuclear Magnetic Resonance Imaging Brain: 1 person, 3.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.33%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 3.33%
Gastrointestinal Stromal Tumor: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol and have Skin hypopigmentation?

- Check whether Skin hypopigmentation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol:

Tylenol (222,310 reports)

Browse all side effects of Tylenol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin hypopigmentation:

Skin hypopigmentation (155 drugs)

Browse all the conditions that are associated with Skin hypopigmentation:

Skin hypopigmentation (286 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Tylenol) and Tylenol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.