Tyrvaya and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Tyrvaya (varenicline tartrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Hydrochlorothiazide, and have Dry eyes.

The phase IV clinical study analyzes which people have Insomnia when taking Tyrvaya. It is created by eHealthMe based on reports of 2,034 people who have side effects when taking Tyrvaya from the FDA, and is updated regularly.

What is Tyrvaya?

Tyrvaya has active ingredients of varenicline tartrate. eHealthMe is studying from 2,034 Tyrvaya users. Check the latest studies of Tyrvaya.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,115 drugs and 5,175 conditions by eHealthMe. Check the latest studies of Insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

2,034 people reported to have side effects when taking Tyrvaya.
Among them, 34 people (1.67%) have Insomnia.

Among these 34 people:

How long have people been on Tyrvaya when they have Insomnia? *

What is the gender of people who have Insomnia when taking Tyrvaya? *

female: 96.15 %
male: 3.85 %

What is the age of people who have Insomnia when taking Tyrvaya? *

What are other drugs people take besides Tyrvaya? *

What are other side effects people have besides Insomnia? *

Sneezing: 7 people, 20.59%
Headache (pain in head): 7 people, 20.59%
Stress And Anxiety: 5 people, 14.71%
Fatigue (feeling of tiredness): 4 people, 11.76%
Throat Irritation: 4 people, 11.76%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 4 people, 11.76%
Nightmares (unpleasant dreams): 4 people, 11.76%
Chills (felling of cold): 3 people, 8.82%
Dyspnea (difficult or laboured breathing): 3 people, 8.82%
Agitation (state of anxiety or nervous excitement): 3 people, 8.82%

What are the existing conditions these people have? *

Dry Eyes (lack of adequate tears): 17 people, 50.00%
Stress And Anxiety: 1 person, 2.94%
Pain: 1 person, 2.94%
Lacrimal Disorder (disease of lacrimal duct): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Tyrvaya and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tyrvaya:

Tyrvaya (2,034 reports)

Insomnia treatments and more:

Insomnia (438,087 reports)

Browse all side effects of Tyrvaya:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,115 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,175 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on varenicline tartrate (the active ingredients of Tyrvaya) and Tyrvaya (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.