Tysabri and Large intestinal obstruction - a phase IV clinical study of FDA data

Summary:

Large intestinal obstruction is reported as a side effect among people who take Tysabri (natalizumab), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Avonex, and have Constipation.

The phase IV clinical study analyzes which people have Large intestinal obstruction when taking Tysabri. It is created by eHealthMe based on reports of 220,870 people who have side effects when taking Tysabri from the FDA, and is updated regularly.

What is Tysabri?

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. eHealthMe is studying from 221,369 Tysabri users. Check the latest studies of Tysabri.

What is Large intestinal obstruction?

Large intestinal obstruction is found to be associated with 278 drugs and 367 conditions by eHealthMe. Check the latest studies of Large intestinal obstruction.

On Jul, 14, 2026

220,870 people reported to have side effects when taking Tysabri.
Among them, 21 people (0.01%) have Large intestinal obstruction.

Could Tysabri cause Large intestinal obstruction?

Among these 21 people:

How long have people been on Tysabri when they have Large intestinal obstruction? *

What is the gender of people who have Large intestinal obstruction when taking Tysabri? *

female: 76.19 %
male: 23.81 %

What is the age of people who have Large intestinal obstruction when taking Tysabri? *

What are other drugs people take besides Tysabri? *

What are other side effects people have besides Large intestinal obstruction? *

Migraine (headache): 4 people, 19.05%
Colon Cancer: 4 people, 19.05%
Constipation: 4 people, 19.05%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 4 people, 19.05%
Abdominal Discomfort: 3 people, 14.29%
Chest Pain: 3 people, 14.29%
Confusional State: 3 people, 14.29%
Drug Hypersensitivity: 3 people, 14.29%
Dyspnea (difficult or laboured breathing): 3 people, 14.29%
Inflammation: 3 people, 14.29%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 9.52%
Constipation: 2 people, 9.52%
Rickets (softening of bones): 1 person, 4.76%
Pain: 1 person, 4.76%
Neuralgia (pain in one or more nerves): 1 person, 4.76%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 1 person, 4.76%
Joint Pain: 1 person, 4.76%
Inflammatory Bowel Disease: 1 person, 4.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.76%
Dementia (madness): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Tysabri and have Large intestinal obstruction?

- Check whether Large intestinal obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tysabri:

Tysabri (221,369 reports)

Browse all side effects of Tysabri:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Large intestinal obstruction:

Large intestinal obstruction (278 drugs)

Browse all the conditions that are associated with Large intestinal obstruction:

Large intestinal obstruction (367 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on natalizumab (the active ingredients of Tysabri) and Tysabri (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.