Uloric and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Uloric (febuxostat), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sciatica when taking Uloric. It is created by eHealthMe based on reports of 7,878 people who have side effects when taking Uloric from the FDA, and is updated regularly.

What is Uloric?

Uloric has active ingredients of febuxostat. It is often used in gout. eHealthMe is studying from 8,067 Uloric users. Check the latest studies of Uloric.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,152 drugs and 1,415 conditions by eHealthMe. Check the latest studies of Sciatica.



On Oct, 20, 2025

7,878 people reported to have side effects when taking Uloric.
Among them, 8 people (0.1%) have Sciatica.

Could Uloric cause Sciatica?

Among these 8 people:

How long have people been on Uloric when they have Sciatica? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Sciatica when taking Uloric? *

  • female: 62.5 %
  • male: 37.5 %

What is the age of people who have Sciatica when taking Uloric? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 71.43 %
  • 60+: 28.57 %

What are other drugs people take besides Uloric? *

  1. Enbrel: 4 people, 50.00%
  2. Humira: 4 people, 50.00%
  3. Actemra: 3 people, 37.50%
  4. Cosentyx: 3 people, 37.50%
  5. Dexilant: 3 people, 37.50%
  6. Codeine: 3 people, 37.50%
  7. Fosamax: 3 people, 37.50%
  8. Gravol: 3 people, 37.50%
  9. Cimzia: 3 people, 37.50%
  10. Ciclosporin: 3 people, 37.50%

What are other side effects people have besides Sciatica? *

  1. Pain: 5 people, 62.50%
  2. Nausea (feeling of having an urge to vomit): 5 people, 62.50%
  3. Feeling Abnormal: 4 people, 50.00%
  4. Asthma: 4 people, 50.00%
  5. Joint Swelling: 4 people, 50.00%
  6. Cataract (clouding of the lens inside the eye): 4 people, 50.00%
  7. Rhinorrhea (watery mucus discharge from the nose): 4 people, 50.00%
  8. Drug Ineffective: 3 people, 37.50%
  9. Drug Intolerance (drug sensitivity): 3 people, 37.50%
  10. Drug Tolerance Decreased: 3 people, 37.50%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 62.50%
  2. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 37.50%
  3. Asthma: 3 people, 37.50%
  4. Rashes (redness): 3 people, 37.50%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 37.50%
  6. Psoriasis (immune-mediated disease that affects the skin): 3 people, 37.50%
  7. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 25.00%
  8. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 25.00%
  9. High Blood Pressure: 1 person, 12.50%
  10. Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Uloric and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Uloric:

Sciatica treatments and more:

How severe was Sciatica and when was it recovered:

Expand to all the drugs that have ingredients of febuxostat:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Uloric:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Browse all the conditions that are associated with Sciatica:

Drugs similar to Uloric and Sciatica :


How the study uses the data?

The study uses data from the FDA. It is based on febuxostat (the active ingredients of Uloric) and Uloric (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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