Uniphyl and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Uniphyl (theophylline), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Singulair, and have Asthma.

The study is created by eHealthMe based on reports of 3,071 people who have side effects when taking Uniphyl from the FDA, and is updated regularly.

What is Uniphyl?

Uniphyl has active ingredients of theophylline. eHealthMe is studying from 3,086 Uniphyl users. Check the latest studies of Uniphyl.

On May, 19, 2026

3,071 people reported to have side effects when taking Uniphyl.
Among them, 99 people (3.22%) died.

Among these 99 people:

How long have people been on Uniphyl when they died? *

What is the gender of people who died when taking Uniphyl? *

female: 43.33 %
male: 56.67 %

What is the age of people who died when taking Uniphyl? *

What are other drugs people take besides Uniphyl? *

What are other side effects people have before they died? *

Acute Kidney Failure: 7 people, 7.07%
Weakness: 5 people, 5.05%
Pain: 5 people, 5.05%
Nausea (feeling of having an urge to vomit): 5 people, 5.05%
Asthma: 4 people, 4.04%
Hypotension (abnormally low blood pressure): 3 people, 3.03%
Paleness (unusual lightness of skin colour): 3 people, 3.03%
Pneumonia: 3 people, 3.03%
Loss Of Consciousness: 3 people, 3.03%
Cough: 3 people, 3.03%

What are the existing conditions these people have? *

Asthma: 22 people, 22.22%
High Blood Pressure: 8 people, 8.08%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 4.04%
Depression: 4 people, 4.04%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 4 people, 4.04%
Stable Angina (a constant chest pain): 4 people, 4.04%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 4 people, 4.04%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 3.03%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 3.03%
Herpes Zoster: 3 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Uniphyl:

Uniphyl (3,086 reports)

Expand to all the drugs that have ingredients of theophylline:

Death and drugs with ingredients of theophylline (708 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Uniphyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,123 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

Related publications that referenced our studies

Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on theophylline (the active ingredients of Uniphyl) and Uniphyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.