Upneeq and Hypertension aggravated - a phase IV clinical study of FDA data

Summary:

Hypertension aggravated is reported as a side effect among people who take Upneeq (oxymetazoline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lisinopril, and have Eyelid ptosis.

The phase IV clinical study analyzes which people have Hypertension aggravated when taking Upneeq. It is created by eHealthMe based on reports of 1,178 people who have side effects when taking Upneeq from the FDA, and is updated regularly.

What is Upneeq?

Upneeq has active ingredients of oxymetazoline hydrochloride. eHealthMe is studying from 1,180 Upneeq users. Check the latest studies of Upneeq.

What is Hypertension aggravated?

Hypertension aggravated (high blood pressure) is found to be associated with 2,739 drugs and 845 conditions by eHealthMe. Check the latest studies of Hypertension aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

1,178 people reported to have side effects when taking Upneeq.
Among them, 35 people (2.97%) have Hypertension aggravated.

Could Upneeq cause Hypertension aggravated?

Among these 35 people:

How long have people been on Upneeq when they have Hypertension aggravated? *

What is the gender of people who have Hypertension aggravated when taking Upneeq? *

female: 91.18 %
male: 8.82 %

What is the age of people who have Hypertension aggravated when taking Upneeq? *

What are other drugs people take besides Upneeq? *

What are other side effects people have besides Hypertension aggravated? *

Vision Blurred: 6 people, 17.14%
Headache (pain in head): 6 people, 17.14%
Dizziness: 4 people, 11.43%
Heart Rate Increased: 3 people, 8.57%
Dry Eyes (lack of adequate tears): 2 people, 5.71%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 5.71%
Migraine With Aura (headache with vision weakness): 2 people, 5.71%
Dry Mouth: 2 people, 5.71%
Weakness: 2 people, 5.71%
Dry Throat: 2 people, 5.71%

What are the existing conditions these people have? *

Eyelid Ptosis (falling of the upper or lower eyelid): 25 people, 71.43%
Stress And Anxiety: 2 people, 5.71%
Dry Eyes (lack of adequate tears): 2 people, 5.71%
Eyelid Twitch (spontaneous and uncontrolled spasms of the muscles): 2 people, 5.71%
Varicose Vein (veins that have become enlarged and tortuous): 1 person, 2.86%
Depression: 1 person, 2.86%
Eye Oedema (swelling or thickening of the macula, the area of the retina responsible for central vision): 1 person, 2.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 2.86%
General Anaesthesia: 1 person, 2.86%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Upneeq and have Hypertension aggravated?

- Check whether Hypertension aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Upneeq:

Upneeq (1,180 reports)

Browse all side effects of Upneeq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertension aggravated:

Hypertension aggravated (2,739 drugs)

Browse all the conditions that are associated with Hypertension aggravated:

Hypertension aggravated (845 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxymetazoline hydrochloride (the active ingredients of Upneeq) and Upneeq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.