Vagifem and Eye pain - a phase IV clinical study of FDA data

Summary:

Eye pain is reported as a side effect among people who take Vagifem (estradiol), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Gabapentin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Eye pain when taking Vagifem. It is created by eHealthMe based on reports of 5,963 people who have side effects when taking Vagifem from the FDA, and is updated regularly.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,263 Vagifem users. Check the latest studies of Vagifem.

What is Eye pain?

Eye pain is found to be associated with 1,759 drugs and 2,465 conditions by eHealthMe. Check the latest studies of Eye pain.

On Jul, 14, 2026

5,963 people reported to have side effects when taking Vagifem.
Among them, 70 people (1.17%) have Eye pain.

Among these 70 people:

How long have people been on Vagifem when they have Eye pain? *

What is the gender of people who have Eye pain when taking Vagifem? *

female: 100 %
male: 0.0 %

What is the age of people who have Eye pain when taking Vagifem? *

What are other drugs people take besides Vagifem? *

What are other side effects people have besides Eye pain? *

Dizziness: 39 people, 55.71%
Dry Mouth: 35 people, 50.00%
Joint Pain: 34 people, 48.57%
Pain In Jaw: 34 people, 48.57%
Pain In Extremity: 33 people, 47.14%
Fever: 33 people, 47.14%
Insomnia (sleeplessness): 32 people, 45.71%
Hypoaesthesia (reduced sense of touch or sensation): 32 people, 45.71%
Metastases To Lung (cancer spreads to lung): 32 people, 45.71%
Metastases To Liver (cancer spreads to liver): 32 people, 45.71%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 12.86%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 8 people, 11.43%
Breast Cancer: 8 people, 11.43%
Metastases To Bone (cancer spreads to bone): 4 people, 5.71%
Dry Eyes (lack of adequate tears): 4 people, 5.71%
Eye Infection: 4 people, 5.71%
Multiple Myeloma (cancer of the plasma cells): 4 people, 5.71%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 4.29%
Urinary Tract Infection: 3 people, 4.29%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Vagifem and have Eye pain?

- Check whether Eye pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vagifem:

Vagifem (6,263 reports)

Eye pain treatments and more:

Eye pain (57,871 reports)

Browse all side effects of Vagifem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eye pain:

Eye pain (1,759 drugs)

Browse all the conditions that are associated with Eye pain:

Eye pain (2,465 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vagifem) and Vagifem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.