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Vagifem and Panic attacks - a phase IV clinical study of FDA data

Summary:

Panic attacks is reported as a side effect among people who take Vagifem (estradiol), especially for people who are female, 60+ old, also take Elmiron, and have Sleep disorder.

The phase IV clinical study analyzes which people have Panic attacks when taking Vagifem. It is created by eHealthMe based on reports of 5,963 people who have side effects when taking Vagifem from the FDA, and is updated regularly.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,262 Vagifem users. Check the latest studies of Vagifem.

What is Panic attacks?

Panic attacks is found to be associated with 2,583 drugs and 2,067 conditions by eHealthMe. Check the latest studies of Panic attacks.

On Sep, 11, 2025

5,963 people reported to have side effects when taking Vagifem.
Among them, 11 people (0.18%) have Panic attacks.

Could Vagifem cause Panic attacks?

Among these 11 people:

What is the gender of people who have Panic attacks when taking Vagifem? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Panic attacks when taking Vagifem? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 27.27 %
  • 60+: 72.73 %

What are other drugs people take besides Vagifem? *

  1. Bystolic: 3 people, 27.27%
  2. Escitalopram: 3 people, 27.27%
  3. Apriso: 3 people, 27.27%
  4. Sertraline: 3 people, 27.27%
  5. Elmiron: 3 people, 27.27%
  6. Diovan: 2 people, 18.18%
  7. Mesalamine: 2 people, 18.18%
  8. Nasonex: 2 people, 18.18%
  9. Pentasa: 2 people, 18.18%
  10. Levothyroxine Sodium: 2 people, 18.18%

What are other side effects people have besides Panic attacks? *

  1. Stress And Anxiety: 6 people, 54.55%
  2. Depression: 4 people, 36.36%
  3. Nausea (feeling of having an urge to vomit): 4 people, 36.36%
  4. Dyspnea (difficult or laboured breathing): 4 people, 36.36%
  5. Depressed Mood: 4 people, 36.36%
  6. Weight Decreased: 3 people, 27.27%
  7. Sleep Disorder: 3 people, 27.27%
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 27.27%
  9. Rashes (redness): 3 people, 27.27%
  10. Irritable Bowel Syndrome: 3 people, 27.27%

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 4 people, 36.36%
  2. Sleep Disorder: 4 people, 36.36%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 27.27%
  4. Arrhythmias (irregular heartbeat): 3 people, 27.27%
  5. Bladder Discomfort: 3 people, 27.27%
  6. Colitis (inflammation of colon): 3 people, 27.27%
  7. Cystitis Interstitial (unknown cause characterized by bladder pain): 3 people, 27.27%
  8. Eye Disorder: 3 people, 27.27%
  9. High Blood Pressure: 3 people, 27.27%
  10. Vaginal Disorder: 3 people, 27.27%

* Approximation only. Some reports may have incomplete information.

Do you take Vagifem and have Panic attacks?

- Check whether Panic attacks is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vagifem:

Panic attacks treatments and more:

How severe was Panic attacks and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vagifem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Panic attacks:

Browse all the conditions that are associated with Panic attacks:

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vagifem) and Vagifem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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