Vagifem and Tension headache - a phase IV clinical study of FDA data

Summary:

Tension headache is reported as a side effect among people who take Vagifem (estradiol), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Simvastatin, and have Osteopenia.

The phase IV clinical study analyzes which people have Tension headache when taking Vagifem. It is created by eHealthMe based on reports of 5,963 people who have side effects when taking Vagifem from the FDA, and is updated regularly.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,263 Vagifem users. Check the latest studies of Vagifem.

What is Tension headache?

Tension headache is found to be associated with 546 drugs and 961 conditions by eHealthMe. Check the latest studies of Tension headache.

On Jul, 21, 2026

5,963 people reported to have side effects when taking Vagifem.
Among them, 11 people (0.18%) have Tension headache.

Among these 11 people:

How long have people been on Vagifem when they have Tension headache? *

What is the gender of people who have Tension headache when taking Vagifem? *

female: 100 %
male: 0.0 %

What is the age of people who have Tension headache when taking Vagifem? *

What are other drugs people take besides Vagifem? *

Dilaudid: 6 people, 54.55%
Premarin: 6 people, 54.55%
Zocor: 6 people, 54.55%
Fosamax: 6 people, 54.55%
Aspirin: 6 people, 54.55%
Niacin: 6 people, 54.55%
Omega-3 Marine Triglycerides: 6 people, 54.55%
Elavil: 6 people, 54.55%
Simvastatin: 6 people, 54.55%
Alendronate Sodium: 5 people, 45.45%

What are other side effects people have besides Tension headache? *

Nausea (feeling of having an urge to vomit): 8 people, 72.73%
Intervertebral Disc Protrusion (spinal disc protrusion): 7 people, 63.64%
Joint Pain: 7 people, 63.64%
Constipation: 7 people, 63.64%
Foot Deformity (functional disability of foot): 6 people, 54.55%
Pain In Extremity: 6 people, 54.55%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 54.55%
Femur Fracture: 6 people, 54.55%
Fever: 6 people, 54.55%
Abdominal Discomfort: 6 people, 54.55%

What are the existing conditions these people have? *

Sleep Disorder: 6 people, 54.55%
Osteoporosis (bones weak and more likely to break): 6 people, 54.55%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 54.55%
Ill-Defined Disorder: 2 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 18.18%
Vulvovaginal Pain: 1 person, 9.09%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 9.09%
Indigestion: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Vagifem and have Tension headache?

- Check whether Tension headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vagifem:

Vagifem (6,263 reports)

Browse all side effects of Vagifem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tension headache:

Tension headache (546 drugs)

Browse all the conditions that are associated with Tension headache:

Tension headache (961 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vagifem) and Vagifem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.