Valacyclovir hydrochloride and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Valacyclovir hydrochloride (valacyclovir hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Constipation.

The phase IV clinical study analyzes which people have Fluid retention when taking Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 12,770 people who have side effects when taking Valacyclovir hydrochloride from the FDA, and is updated regularly.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,704 drugs and 2,443 conditions by eHealthMe. Check the latest studies of Fluid retention.

On Apr, 11, 2026

12,770 people reported to have side effects when taking Valacyclovir hydrochloride.
Among them, 38 people (0.3%) have Fluid retention.

Could Valacyclovir hydrochloride cause Fluid retention?

Among these 38 people:

How long have people been on Valacyclovir hydrochloride when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Valacyclovir hydrochloride? *

female: 59.38 %
male: 40.62 %

What is the age of people who have Fluid retention when taking Valacyclovir hydrochloride? *

What are other drugs people take besides Valacyclovir hydrochloride? *

What are other side effects people have besides Fluid retention? *

Fatigue (feeling of tiredness): 11 people, 28.95%
Fall: 9 people, 23.68%
Infection: 9 people, 23.68%
Fever: 9 people, 23.68%
Cough: 9 people, 23.68%
High Blood Pressure: 8 people, 21.05%
Weakness: 7 people, 18.42%
Thrombocytopenia (decrease of platelets in blood): 7 people, 18.42%
Drug Ineffective: 7 people, 18.42%
Nausea (feeling of having an urge to vomit): 7 people, 18.42%

What are the existing conditions these people have? *

Constipation: 7 people, 18.42%
Gastric Ulcer (stomach ulcer): 5 people, 13.16%
Thrombocytopenia (decrease of platelets in blood): 4 people, 10.53%
Lacrimation Increased: 4 people, 10.53%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 4 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 4 people, 10.53%
Nausea And Vomiting: 4 people, 10.53%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 10.53%
Anaemia (lack of blood): 3 people, 7.89%
Muscle Spasms (muscle contraction): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir hydrochloride and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir hydrochloride:

Valacyclovir hydrochloride (12,929 reports)

Fluid retention treatments and more:

Fluid retention (79,660 reports)

Browse all side effects of Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,704 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,443 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir hydrochloride) and Valacyclovir hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.