Valacyclovir hydrochloride and Optic neuropathy - a phase IV clinical study of FDA data

Summary:

Optic neuropathy is reported as a side effect among people who take Valacyclovir hydrochloride (valacyclovir hydrochloride), especially for people who are male, 30-39 old, also take Amitriptyline Hydrochloride, and have Chronic graft versus host disease.

The phase IV clinical study analyzes which people have Optic neuropathy when taking Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 12,770 people who have side effects when taking Valacyclovir hydrochloride from the FDA, and is updated regularly.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

What is Optic neuropathy?

Optic neuropathy (optic nerve damage) is found to be associated with 258 drugs and 452 conditions by eHealthMe. Check the latest studies of Optic neuropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

12,770 people reported to have side effects when taking Valacyclovir hydrochloride.
Among them, 12 people (0.09%) have Optic neuropathy.

Could Valacyclovir hydrochloride cause Optic neuropathy?

Among these 12 people:

What is the gender of people who have Optic neuropathy when taking Valacyclovir hydrochloride? *

female: 0.0 %
male: 100 %

What is the age of people who have Optic neuropathy when taking Valacyclovir hydrochloride? *

What are other drugs people take besides Valacyclovir hydrochloride? *

Amitriptyline Hydrochloride: 12 people, 100.00%
Posaconazole: 11 people, 91.67%
Entecavir: 11 people, 91.67%
Sulfamethoxazole: 11 people, 91.67%
Trimethoprim: 11 people, 91.67%
Prednisone: 11 people, 91.67%
Methotrexate: 10 people, 83.33%
Prevymis: 8 people, 66.67%
Potassium Chloride: 1 person, 8.33%
Omacor: 1 person, 8.33%

What are the existing conditions these people have? *

Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 11 people, 91.67%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir hydrochloride and have Optic neuropathy?

- Check whether Optic neuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir hydrochloride:

Valacyclovir hydrochloride (12,929 reports)

Browse all side effects of Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic neuropathy:

Optic neuropathy (258 drugs)

Browse all the conditions that are associated with Optic neuropathy:

Optic neuropathy (452 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir hydrochloride) and Valacyclovir hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.