Valacyclovir hydrochloride and Periodontitis - a phase IV clinical study of FDA data

Summary:

Periodontitis is reported as a side effect among people who take Valacyclovir hydrochloride (valacyclovir hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Valsartan, and have High blood pressure.

The phase IV clinical study analyzes which people have Periodontitis when taking Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 12,770 people who have side effects when taking Valacyclovir hydrochloride from the FDA, and is updated regularly.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

What is Periodontitis?

Periodontitis (inflammation of the tissue around the teeth) is found to be associated with 641 drugs and 709 conditions by eHealthMe. Check the latest studies of Periodontitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

12,770 people reported to have side effects when taking Valacyclovir hydrochloride.
Among them, 11 people (0.09%) have Periodontitis.

Could Valacyclovir hydrochloride cause Periodontitis?

Among these 11 people:

How long have people been on Valacyclovir hydrochloride when they have Periodontitis? *

What is the gender of people who have Periodontitis when taking Valacyclovir hydrochloride? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Periodontitis when taking Valacyclovir hydrochloride? *

What are other drugs people take besides Valacyclovir hydrochloride? *

What are other side effects people have besides Periodontitis? *

Gingival Ulceration (ulcer on gums): 10 people, 90.91%
Periodontal Disease (disease that attacks the gum and bone and around the teeth): 10 people, 90.91%
Pain In Jaw: 10 people, 90.91%
Osteonecrosis Of Jaw (death of bone of jaw): 10 people, 90.91%
Oral Pain: 10 people, 90.91%
Oral Herpes (viral infection of mouth): 10 people, 90.91%
Necrosis (the death of body tissue): 10 people, 90.91%
Gastroenteritis (inflammation of stomach and intestine): 10 people, 90.91%
C-Reactive Protein Increased: 2 people, 18.18%
Lymphopenia (an abnormally low level of lymphocytes in the blood): 2 people, 18.18%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 90.91%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 10 people, 90.91%
Oral Herpes (viral infection of mouth): 10 people, 90.91%
High Blood Pressure: 10 people, 90.91%
Osteoporosis (bones weak and more likely to break): 5 people, 45.45%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir hydrochloride and have Periodontitis?

- Check whether Periodontitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir hydrochloride:

Valacyclovir hydrochloride (12,929 reports)

Periodontitis treatments and more:

Periodontitis (4,596 reports)

Browse all side effects of Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Periodontitis:

Periodontitis (641 drugs)

Browse all the conditions that are associated with Periodontitis:

Periodontitis (709 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir hydrochloride) and Valacyclovir hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.