Valacyclovir and Chronic graft versus host disease - a phase IV clinical study of FDA data

Summary:

Chronic graft versus host disease is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Cyclosporine, and have Gastrointestinal toxicity.

The phase IV clinical study analyzes which people have Chronic graft versus host disease when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,108 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Chronic graft versus host disease?

Chronic graft versus host disease (immune cells attack the host's body cells after transplant) is found to be associated with 171 drugs and 328 conditions by eHealthMe. Check the latest studies of Chronic graft versus host disease.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 26 people (0.06%) have Chronic graft versus host disease.

Could Valacyclovir cause Chronic graft versus host disease?

Among these 26 people:

How long have people been on Valacyclovir when they have Chronic graft versus host disease? *

What is the gender of people who have Chronic graft versus host disease when taking Valacyclovir? *

female: 30 %
male: 70 %

What is the age of people who have Chronic graft versus host disease when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

What are other side effects people have besides Chronic graft versus host disease? *

Diarrhea: 6 people, 23.08%
Itching: 5 people, 19.23%
Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 5 people, 19.23%
Joint Range Of Motion Decreased (disease of joint movement): 4 people, 15.38%
Rashes (redness): 4 people, 15.38%
Nausea (feeling of having an urge to vomit): 4 people, 15.38%
Fatigue (feeling of tiredness): 4 people, 15.38%
Restrictive Pulmonary Disease (reduction in total lung capacity): 4 people, 15.38%
Cytomegalovirus Infection: 4 people, 15.38%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 15.38%

What are the existing conditions these people have? *

Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 4 people, 15.38%
Chronic Graft Versus Host Disease In Skin (damage by immune cells to skin after grafting): 4 people, 15.38%
Gastrointestinal Toxicity (damage to digestive tract by any substance): 4 people, 15.38%
Liver Disorder (liver diseases): 3 people, 11.54%
Bone Marrow Conditioning Regimen: 3 people, 11.54%
Graft Versus Host Disease In Liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver): 3 people, 11.54%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 11.54%
Oral Discomfort (pain or irritation in mouth): 2 people, 7.69%
Back Pain: 2 people, 7.69%
Joint Pain: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Chronic graft versus host disease?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,108 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chronic graft versus host disease:

Chronic graft versus host disease (171 drugs)

Browse all the conditions that are associated with Chronic graft versus host disease:

Chronic graft versus host disease (328 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.