Valacyclovir and Generalised oedema - a phase IV clinical study of FDA data

Summary:

Generalised oedema is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Bactrim, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Generalised oedema when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,108 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Generalised oedema?

Generalised oedema (swelling all over the body) is found to be associated with 1,088 drugs and 1,406 conditions by eHealthMe. Check the latest studies of Generalised oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 43 people (0.1%) have Generalised oedema.

Could Valacyclovir cause Generalised oedema?

Among these 43 people:

How long have people been on Valacyclovir when they have Generalised oedema? *

What is the gender of people who have Generalised oedema when taking Valacyclovir? *

female: 65 %
male: 35 %

What is the age of people who have Generalised oedema when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

Bactrim: 21 people, 48.84%
Dexamethasone: 13 people, 30.23%
Furosemide: 11 people, 25.58%
Melatonin: 9 people, 20.93%
Amiloride Hydrochloride: 8 people, 18.60%
Velcade: 8 people, 18.60%
Cyclophosphamide: 8 people, 18.60%
Amoxicillin: 8 people, 18.60%
Midodrine Hydrochloride: 8 people, 18.60%
Ondansetron: 6 people, 13.95%

What are other side effects people have besides Generalised oedema? *

Rashes (redness): 11 people, 25.58%
Thrombocytopenia (decrease of platelets in blood): 10 people, 23.26%
Itching: 9 people, 20.93%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 8 people, 18.60%
Ascites (accumulation of fluid in the abdominal cavity): 7 people, 16.28%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 6 people, 13.95%
Anaemia (lack of blood): 6 people, 13.95%
Fever: 6 people, 13.95%
Dyspnea (difficult or laboured breathing): 6 people, 13.95%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 5 people, 11.63%

What are the existing conditions these people have? *

Primary Amyloidosis (disease that occurs when substances called amyloid proteins build up in your organs): 8 people, 18.60%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 8 people, 18.60%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 8 people, 18.60%
Anaemia (lack of blood): 6 people, 13.95%
High Blood Pressure: 6 people, 13.95%
Multiple Myeloma (cancer of the plasma cells): 4 people, 9.30%
Pain: 4 people, 9.30%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 6.98%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 6.98%
Skin Exfoliation (removal of the oldest dead skin cells): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Generalised oedema?

- Check whether Generalised oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,108 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Generalised oedema:

Generalised oedema (1,088 drugs)

Browse all the conditions that are associated with Generalised oedema:

Generalised oedema (1,406 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.