Valacyclovir and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Bactrim, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Hepatic failure when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,542 drugs and 1,888 conditions by eHealthMe. Check the latest studies of Hepatic failure.

On Apr, 24, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 86 people (0.21%) have Hepatic failure.

Could Valacyclovir cause Hepatic failure?

Among these 86 people:

How long have people been on Valacyclovir when they have Hepatic failure? *

What is the gender of people who have Hepatic failure when taking Valacyclovir? *

female: 48 %
male: 52 %

What is the age of people who have Hepatic failure when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

What are other side effects people have besides Hepatic failure? *

Thrombocytopenia (decrease of platelets in blood): 23 people, 26.74%
Acute Kidney Failure: 21 people, 24.42%
Diarrhea: 17 people, 19.77%
Fever: 15 people, 17.44%
Hepatitis Fulminant (life-threatening condition defined by significantly impaired liver function): 13 people, 15.12%
Leukopenia (less number of white blood cells in blood): 12 people, 13.95%
Pleural Effusion (water on the lungs): 11 people, 12.79%
Pneumonia: 11 people, 12.79%
Sepsis (a severe blood infection that can lead to organ failure and death): 10 people, 11.63%
Ascites (accumulation of fluid in the abdominal cavity): 10 people, 11.63%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 12.79%
Pneumonia: 8 people, 9.30%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 8.14%
Fever: 7 people, 8.14%
Immunodeficiency Common Variable: 7 people, 8.14%
High Blood Pressure: 6 people, 6.98%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 5.81%
Pain: 5 people, 5.81%
Mantle Cell Lymphoma Stage Iii (cancer of lymphocytes, a type of white blood cell- stage iii): 5 people, 5.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,107 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,542 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,888 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.