Valacyclovir and Injection site discomfort - a phase IV clinical study of FDA data

Summary:

Injection site discomfort is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are female, 40-49 old, also take Hydromorphone Hydrochloride, and have Arthritis.

The phase IV clinical study analyzes which people have Injection site discomfort when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Injection site discomfort?

Injection site discomfort is found to be associated with 411 drugs and 382 conditions by eHealthMe. Check the latest studies of Injection site discomfort.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 12 people (0.03%) have Injection site discomfort.

Could Valacyclovir cause Injection site discomfort?

Among these 12 people:

What is the gender of people who have Injection site discomfort when taking Valacyclovir? *

female: 100 %
male: 0.0 %

What is the age of people who have Injection site discomfort when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

Xopenex: 3 people, 25.00%
Multivitamin: 3 people, 25.00%
Amlodipine: 3 people, 25.00%
Chlorthalidone: 3 people, 25.00%
Desloratadine: 3 people, 25.00%
Epinephrine: 3 people, 25.00%
Fentanyl: 3 people, 25.00%
Flagyl: 3 people, 25.00%
Gabapentin: 3 people, 25.00%
Hydromorphone Hydrochloride: 3 people, 25.00%

What are other side effects people have besides Injection site discomfort? *

Pain: 9 people, 75.00%
Abdominal Discomfort: 7 people, 58.33%
High Blood Pressure: 7 people, 58.33%
Fatigue (feeling of tiredness): 6 people, 50.00%
Stress And Anxiety: 6 people, 50.00%
Injection Site Pain: 6 people, 50.00%
Sinusitis (inflammation of sinus): 6 people, 50.00%
Headache (pain in head): 6 people, 50.00%
Otitis (ear infection): 6 people, 50.00%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 50.00%

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 25.00%
Immunodeficiency Common Variable: 3 people, 25.00%
Constipation: 3 people, 25.00%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 3 people, 25.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 16.67%
Skin Wrinkling (wrinkle on skin): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Injection site discomfort?

- Check whether Injection site discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,107 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site discomfort:

Injection site discomfort (411 drugs)

Browse all the conditions that are associated with Injection site discomfort:

Injection site discomfort (382 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.