Valacyclovir and Nail discoloration - a phase IV clinical study of FDA data

Summary:

Nail discoloration is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Celebrex, and have Dyspnea.

The phase IV clinical study analyzes which people have Nail discoloration when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,108 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Nail discoloration?

Nail discoloration is found to be associated with 415 drugs and 989 conditions by eHealthMe. Check the latest studies of Nail discoloration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 20 people (0.05%) have Nail discoloration.

Could Valacyclovir cause Nail discoloration?

Among these 20 people:

How long have people been on Valacyclovir when they have Nail discoloration? *

What is the gender of people who have Nail discoloration when taking Valacyclovir? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Nail discoloration when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

Pennsaid: 12 people, 60.00%
Gabapentin: 12 people, 60.00%
Cetirizine Hydrochloride: 12 people, 60.00%
Tylenol: 12 people, 60.00%
Paclitaxel: 12 people, 60.00%
Celebrex: 12 people, 60.00%
Aspirin: 11 people, 55.00%
Amlodipine Besylate: 8 people, 40.00%
Terbutaline Sulfate: 8 people, 40.00%
Spiriva: 8 people, 40.00%

What are other side effects people have besides Nail discoloration? *

Urinary Tract Infection: 13 people, 65.00%
Joint Pain: 13 people, 65.00%
High Blood Pressure: 12 people, 60.00%
Drug Ineffective: 12 people, 60.00%
Onychalgia (nail biting): 12 people, 60.00%
Nosebleed (bleeding from nose): 12 people, 60.00%
Nail Discomfort: 12 people, 60.00%
Pneumonia Viral: 12 people, 60.00%
Micturition Urgency (urgency to pass the urine): 12 people, 60.00%
Ligament Sprain (ligament stretched): 12 people, 60.00%

What are the existing conditions these people have? *

Back Pain: 12 people, 60.00%
Ovarian Cancer (cancer of ovary): 12 people, 60.00%
Oral Herpes (viral infection of mouth): 12 people, 60.00%
Joint Pain: 12 people, 60.00%
High Blood Pressure: 12 people, 60.00%
Dyspnea (difficult or laboured breathing): 12 people, 60.00%
Cellulitis (infection under the skin): 6 people, 30.00%
Cough: 5 people, 25.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 5.00%
Bone Disorder: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Nail discoloration?

- Check whether Nail discoloration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,108 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nail discoloration:

Nail discoloration (415 drugs)

Browse all the conditions that are associated with Nail discoloration:

Nail discoloration (989 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.