Valproate sodium and Gingival hyperplasia - a phase IV clinical study of FDA data

Summary:

Gingival hyperplasia is reported as a side effect among people who take Valproate sodium (valproate sodium), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Phenytoin, and have Autism.

The phase IV clinical study analyzes which people have Gingival hyperplasia when taking Valproate sodium. It is created by eHealthMe based on reports of 23,476 people who have side effects when taking Valproate sodium from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Gingival hyperplasia?

Gingival hyperplasia (overgrowth of gums) is found to be associated with 154 drugs and 263 conditions by eHealthMe. Check the latest studies of Gingival hyperplasia.

On Aug, 04, 2026

23,476 people reported to have side effects when taking Valproate sodium.
Among them, 17 people (0.07%) have Gingival hyperplasia.

Could Valproate sodium cause Gingival hyperplasia?

Among these 17 people:

How long have people been on Valproate sodium when they have Gingival hyperplasia? *

What is the gender of people who have Gingival hyperplasia when taking Valproate sodium? *

female: 53.33 %
male: 46.67 %

What is the age of people who have Gingival hyperplasia when taking Valproate sodium? *

What are other drugs people take besides Valproate sodium? *

What are other side effects people have besides Gingival hyperplasia? *

Fatigue (feeling of tiredness): 4 people, 23.53%
Diplopia (double vision): 3 people, 17.65%
Oedema Peripheral (superficial swelling): 3 people, 17.65%
Dyspnea (difficult or laboured breathing): 3 people, 17.65%
Gingival Bleeding (bleeding gums): 3 people, 17.65%
Periodontitis (inflammation of the tissue around the teeth): 3 people, 17.65%
Drowsiness: 3 people, 17.65%
Nausea (feeling of having an urge to vomit): 3 people, 17.65%
Constipation: 3 people, 17.65%
Hair Loss: 3 people, 17.65%

What are the existing conditions these people have? *

Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts): 3 people, 17.65%
Stress And Anxiety: 2 people, 11.76%
Sleep Disorder: 2 people, 11.76%
Depression: 2 people, 11.76%
Cluster Headache (one-sided head pain with tearing): 2 people, 11.76%
Schizophreniform Disorder (mental disorder is diagnosed when the symptom criteria for schizophrenia are met, but the duration is too short and social and occupational functioning): 1 person, 5.88%
Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 5.88%
Infantile Spasms: 1 person, 5.88%
Drug Exposure During Pregnancy: 1 person, 5.88%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Valproate sodium and have Gingival hyperplasia?

- Check whether Gingival hyperplasia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproate sodium:

Valproate sodium (24,044 reports)

Browse all side effects of Valproate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gingival hyperplasia:

Gingival hyperplasia (154 drugs)

Browse all the conditions that are associated with Gingival hyperplasia:

Gingival hyperplasia (263 conditions)

Related publications that referenced our studies

Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
Raheel SA, Kujan OB, Tarakji B, Umar D, Ibrahim S, "Propranolol-induced gingival hyperplasia with Nager syndrome: A rare adverse drug reaction", Journal of advanced pharmaceutical technology & research, 2016 Jan .
Bansal S, Gupta SK, "Sodium Valproate induced priapism in an adult with bipolar affective disorder", Indian journal of pharmacology, 2013 Jan .
Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
Raheel SA, Kujan OB, Tarakji B, Umar D, Ibrahim S, "Propranolol-induced gingival hyperplasia with Nager syndrome: A rare adverse drug reaction", Journal of advanced pharmaceutical technology & research, 2016 Jan .
Bansal S, Gupta SK, "Sodium Valproate induced priapism in an adult with bipolar affective disorder", Indian journal of pharmacology, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on valproate sodium (the active ingredients of Valproate sodium) and Valproate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.