Valproate sodium and Gingival hypertrophy - a phase IV clinical study of FDA data

Summary:

Gingival hypertrophy is reported as a side effect among people who take Valproate sodium (valproate sodium), especially for people who are female, 20-29 old, also take Phenytoin, and have Convulsion.

The phase IV clinical study analyzes which people have Gingival hypertrophy when taking Valproate sodium. It is created by eHealthMe based on reports of 23,476 people who have side effects when taking Valproate sodium from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Gingival hypertrophy?

Gingival hypertrophy (overgrowth of gums) is found to be associated with 121 drugs and 206 conditions by eHealthMe. Check the latest studies of Gingival hypertrophy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

23,476 people reported to have side effects when taking Valproate sodium.
Among them, 17 people (0.07%) have Gingival hypertrophy.

Could Valproate sodium cause Gingival hypertrophy?

Among these 17 people:

What is the gender of people who have Gingival hypertrophy when taking Valproate sodium? *

female: 76.47 %
male: 23.53 %

What is the age of people who have Gingival hypertrophy when taking Valproate sodium? *

What are other drugs people take besides Valproate sodium? *

What are other side effects people have besides Gingival hypertrophy? *

Eye Movements - Uncontrollable: 3 people, 17.65%
Cerebellar Atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements): 3 people, 17.65%
Movement - Uncoordinated: 3 people, 17.65%
Graft Infection (infection of graft site): 2 people, 11.76%
Haemoglobin Decreased: 2 people, 11.76%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 2 people, 11.76%
Kidney Transplant Rejection: 2 people, 11.76%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 11.76%
Nephropathy (damage to or disease of a kidney): 2 people, 11.76%
Oedema (fluid collection in tissue): 2 people, 11.76%

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 29.41%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 17.65%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 1 person, 5.88%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Valproate sodium and have Gingival hypertrophy?

- Check whether Gingival hypertrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproate sodium:

Valproate sodium (24,044 reports)

Browse all side effects of Valproate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gingival hypertrophy:

Gingival hypertrophy (121 drugs)

Browse all the conditions that are associated with Gingival hypertrophy:

Gingival hypertrophy (206 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproate sodium (the active ingredients of Valproate sodium) and Valproate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.