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Valproate sodium and Systolic dysfunction - a phase IV clinical study of FDA data

Summary:

Systolic dysfunction is reported as a side effect among people who take Valproate sodium (valproate sodium), especially for people who are male, 40-49 old, also take Aripiprazole, and have Dyslipidaemia.

The phase IV clinical study analyzes which people have Systolic dysfunction when taking Valproate sodium. It is created by eHealthMe based on reports of 23,476 people who have side effects when taking Valproate sodium from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Systolic dysfunction?

Systolic dysfunction (impaired ventricular contraction) is found to be associated with 197 drugs and 220 conditions by eHealthMe. Check the latest studies of Systolic dysfunction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

23,476 people reported to have side effects when taking Valproate sodium.
Among them, 20 people (0.09%) have Systolic dysfunction.

Could Valproate sodium cause Systolic dysfunction?

Among these 20 people:

What is the gender of people who have Systolic dysfunction when taking Valproate sodium? *

  • female: 5 %
  • male: 95 %

What is the age of people who have Systolic dysfunction when taking Valproate sodium? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.88 %
  • 30-39: 35.29 %
  • 40-49: 47.06 %
  • 50-59: 0.0 %
  • 60+: 11.76 %

What are other drugs people take besides Valproate sodium? *

  1. Aripiprazole: 14 people, 70.00%
  2. Lithium Carbonate: 12 people, 60.00%
  3. Olanzapine: 11 people, 55.00%
  4. Furosemide: 10 people, 50.00%
  5. Melatonin: 10 people, 50.00%
  6. Atorvastatin Calcium: 10 people, 50.00%
  7. Ryzodeg 70/30: 9 people, 45.00%
  8. Prazosin Hydrochloride: 9 people, 45.00%
  9. Amlodipine Besylate: 8 people, 40.00%
  10. Clozaril: 6 people, 30.00%

What are other side effects people have besides Systolic dysfunction? *

  1. Echocardiogram Abnormal: 12 people, 60.00%
  2. High Blood Cholesterol: 11 people, 55.00%
  3. Globulins Increased: 10 people, 50.00%
  4. Red Cell Distribution Width Increased: 10 people, 50.00%
  5. Blood Urea Increased: 10 people, 50.00%
  6. Blood Thyroid Stimulating Hormone Increased: 10 people, 50.00%
  7. Neutrophil Count Increased (excess than normal number of neutrophil a type of blood cell): 10 people, 50.00%
  8. Haemoglobin Decreased: 10 people, 50.00%
  9. Blood Alkaline Phosphatase Increased: 10 people, 50.00%
  10. Blood Albumin Decreased: 10 people, 50.00%

What are the existing conditions these people have? *

  1. Type 1 Diabetes: 8 people, 40.00%
  2. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 8 people, 40.00%
  3. High Blood Pressure: 8 people, 40.00%
  4. Dyslipidaemia (abnormal amount of lipids): 8 people, 40.00%
  5. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 30.00%
  6. Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 5.00%
  7. Osteoporosis (bones weak and more likely to break): 1 person, 5.00%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.00%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%
  10. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Valproate sodium and have Systolic dysfunction?

- Check whether Systolic dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproate sodium:

Systolic dysfunction treatments and more:

How severe was Systolic dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of valproate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systolic dysfunction:

Browse all the conditions that are associated with Systolic dysfunction:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproate sodium (the active ingredients of Valproate sodium) and Valproate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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