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Valproic acid and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are female, 40-49 old, also take Lamivudine, and have Hypotension.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 965 drugs and 1,094 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 24 people (0.07%) have Adrenal insufficiency.

Could Valproic acid cause Adrenal insufficiency?

Among these 24 people:

What is the gender of people who have Adrenal insufficiency when taking Valproic acid? *

  • female: 70.83 %
  • male: 29.17 %

What is the age of people who have Adrenal insufficiency when taking Valproic acid? *

  • 0-1: 4.17 %
  • 2-9: 0.0 %
  • 10-19: 8.33 %
  • 20-29: 4.17 %
  • 30-39: 4.17 %
  • 40-49: 58.33 %
  • 50-59: 0.0 %
  • 60+: 20.83 %

What are other drugs people take besides Valproic acid? *

  1. Crixivan: 14 people, 58.33%
  2. Lamivudine: 14 people, 58.33%
  3. Pyrimethamine: 13 people, 54.17%
  4. Stavudine: 9 people, 37.50%
  5. Zerit: 5 people, 20.83%
  6. Carbamazepine: 3 people, 12.50%
  7. Clindamycin Hydrochloride: 3 people, 12.50%
  8. Zoloft: 1 person, 4.17%
  9. Keppra: 1 person, 4.17%
  10. Clonazepam: 1 person, 4.17%

What are other side effects people have besides Adrenal insufficiency? *

  1. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 16 people, 66.67%
  2. Lactic Acidosis (low ph in body tissues): 15 people, 62.50%
  3. Fatty Liver: 14 people, 58.33%
  4. Gamma-Glutamyltransferase Increased: 13 people, 54.17%
  5. Cytomegalovirus Infection: 4 people, 16.67%
  6. Alanine Aminotransferase Increased: 4 people, 16.67%
  7. Blood Alkaline Phosphatase Nos Increased: 4 people, 16.67%
  8. Aspartate Aminotransferase Increased: 4 people, 16.67%
  9. Hypotension (abnormally low blood pressure): 3 people, 12.50%
  10. Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 8.33%

What are the existing conditions these people have? *

  1. Sleep Disorder: 1 person, 4.17%
  2. Skin Irritation: 1 person, 4.17%
  3. Restrictive Pulmonary Disease (reduction in total lung capacity): 1 person, 4.17%
  4. Respiratory Tract Infection: 1 person, 4.17%
  5. Post-Traumatic Epilepsy: 1 person, 4.17%
  6. Pain: 1 person, 4.17%
  7. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 4.17%
  8. Lung Disorder (lung disease): 1 person, 4.17%
  9. Hypovolaemic Shock (shock caused by severe blood or fluid loss): 1 person, 4.17%
  10. Hypotension (abnormally low blood pressure): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Adrenal insufficiency treatments and more:

How severe was Adrenal insufficiency and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Browse all the conditions that are associated with Adrenal insufficiency:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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