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Valproic acid and Astigmatism - a phase IV clinical study of FDA data

Summary:

Astigmatism is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are male, 0-1 old, also take Folic Acid, and have Drug exposure during pregnancy.

The phase IV clinical study analyzes which people have Astigmatism when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Astigmatism?

Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina) is found to be associated with 369 drugs and 416 conditions by eHealthMe. Check the latest studies of Astigmatism.

On Jul, 28, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 33 people (0.09%) have Astigmatism.

Could Valproic acid cause Astigmatism?

Among these 33 people:

What is the gender of people who have Astigmatism when taking Valproic acid? *

  • female: 30 %
  • male: 70 %

What is the age of people who have Astigmatism when taking Valproic acid? *

  • 0-1: 54.55 %
  • 2-9: 18.18 %
  • 10-19: 18.18 %
  • 20-29: 9.09 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Valproic acid? *

  1. Folic Acid: 6 people, 18.18%
  2. Lorazepam: 2 people, 6.06%
  3. Selenium: 2 people, 6.06%
  4. Vitamin K1: 2 people, 6.06%
  5. Levothyroxine Sodium: 1 person, 3.03%
  6. Benadryl: 1 person, 3.03%
  7. Clobazam: 1 person, 3.03%
  8. Epinephrine: 1 person, 3.03%
  9. Glycolax: 1 person, 3.03%
  10. Lamictal: 1 person, 3.03%

What are other side effects people have besides Astigmatism? *

  1. Dysmorphism (difference of body structure that is suggestive of a congenital disorder): 20 people, 60.61%
  2. Speech Disorder Developmental: 18 people, 54.55%
  3. Foetal Anticonvulsant Syndrome (malformations and developmental delay in children due to intake of anticonvulsant drugs in pregnancy): 17 people, 51.52%
  4. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 17 people, 51.52%
  5. Developmental Delay: 13 people, 39.39%
  6. Abnormal Behavior: 11 people, 33.33%
  7. Drug Exposure During Pregnancy: 11 people, 33.33%
  8. Coordination Abnormal (abnormal movement): 10 people, 30.30%
  9. Disturbance In Attention: 9 people, 27.27%
  10. Strabismus (a disorder in which the two eyes do not line up in the same direction): 9 people, 27.27%

What are the existing conditions these people have? *

  1. Drug Exposure During Pregnancy: 11 people, 33.33%
  2. Stress And Anxiety: 1 person, 3.03%
  3. Maternal Exposure During Pregnancy (use of substance during pregnancy): 1 person, 3.03%
  4. Insomnia (sleeplessness): 1 person, 3.03%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 3.03%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.03%
  7. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 1 person, 3.03%
  8. Dermatitis Diaper (diaper rash is a common form of inflamed skin): 1 person, 3.03%
  9. Constipation: 1 person, 3.03%
  10. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Astigmatism?

- Check whether Astigmatism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Astigmatism treatments and more:

How severe was Astigmatism and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Astigmatism:

Browse all the conditions that are associated with Astigmatism:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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