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Valproic acid and Gingival disorder - a phase IV clinical study of FDA data

Summary:

Gingival disorder is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are female, 60+ old, also take Lamotrigine, and have Euphoric mood.

The phase IV clinical study analyzes which people have Gingival disorder when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Gingival disorder?

Gingival disorder (gum disease) is found to be associated with 665 drugs and 572 conditions by eHealthMe. Check the latest studies of Gingival disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 18 people (0.05%) have Gingival disorder.

Could Valproic acid cause Gingival disorder?

Among these 18 people:

What is the gender of people who have Gingival disorder when taking Valproic acid? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Gingival disorder when taking Valproic acid? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 5.56 %
  • 20-29: 0.0 %
  • 30-39: 11.11 %
  • 40-49: 16.67 %
  • 50-59: 16.67 %
  • 60+: 50.0 %

What are other drugs people take besides Valproic acid? *

  1. Midazolam: 7 people, 38.89%
  2. Mirtazapine: 7 people, 38.89%
  3. Zonisamide: 7 people, 38.89%
  4. Aspirin: 7 people, 38.89%
  5. Brivaracetam: 7 people, 38.89%
  6. Clobazam: 7 people, 38.89%
  7. Gabapentin: 7 people, 38.89%
  8. Lacosamide: 7 people, 38.89%
  9. Phenytoin: 7 people, 38.89%
  10. Lamotrigine: 7 people, 38.89%

What are other side effects people have besides Gingival disorder? *

  1. Tooth Disorder (tooth disease): 9 people, 50.00%
  2. Gait Disturbance: 8 people, 44.44%
  3. Hypersensitivity: 7 people, 38.89%
  4. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 7 people, 38.89%
  5. Dizziness: 7 people, 38.89%
  6. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 7 people, 38.89%
  7. Postictal Paralysis: 7 people, 38.89%
  8. Depressed Mood: 7 people, 38.89%
  9. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 7 people, 38.89%
  10. Overdose: 7 people, 38.89%

What are the existing conditions these people have? *

  1. Renal Cell Carcinoma (a kidney cancer): 2 people, 11.11%
  2. Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 11.11%
  3. Euphoric Mood (excessively happy but may become angry or irritable): 2 people, 11.11%
  4. Osteoporosis (bones weak and more likely to break): 1 person, 5.56%
  5. Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 5.56%
  6. Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 1 person, 5.56%
  7. Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 1 person, 5.56%
  8. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 1 person, 5.56%
  9. Complex Partial Seizures (epileptic seizure): 1 person, 5.56%
  10. Agitation (state of anxiety or nervous excitement): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Gingival disorder?

- Check whether Gingival disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Gingival disorder treatments and more:

How severe was Gingival disorder and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gingival disorder:

Browse all the conditions that are associated with Gingival disorder:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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