Valproic acid and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Vimpat, and have Complex partial seizures.

The phase IV clinical study analyzes which people have Joint stiffness when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,297 drugs and 1,340 conditions by eHealthMe. Check the latest studies of Joint stiffness.

On Aug, 06, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 18 people (0.05%) have Joint stiffness.

Could Valproic acid cause Joint stiffness?

Among these 18 people:

How long have people been on Valproic acid when they have Joint stiffness? *

What is the gender of people who have Joint stiffness when taking Valproic acid? *

female: 43.75 %
male: 56.25 %

What is the age of people who have Joint stiffness when taking Valproic acid? *

What are other drugs people take besides Valproic acid? *

What are other side effects people have besides Joint stiffness? *

Joint Pain: 6 people, 33.33%
Fall: 5 people, 27.78%
Dizziness: 5 people, 27.78%
Pain In Extremity: 4 people, 22.22%
Fatigue (feeling of tiredness): 4 people, 22.22%
Depressed Level Of Consciousness: 4 people, 22.22%
Difficulty In Walking: 3 people, 16.67%
Hypotension (abnormally low blood pressure): 3 people, 16.67%
Agitation (state of anxiety or nervous excitement): 3 people, 16.67%
Confusional State: 3 people, 16.67%

What are the existing conditions these people have? *

Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 4 people, 22.22%
Complex Partial Seizures (epileptic seizure): 4 people, 22.22%
Psychotic Disorder: 2 people, 11.11%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 11.11%
Essential Hypertension (primary hypertension): 2 people, 11.11%
Tardive Dyskinesia (a disorder that involves involuntary movements): 1 person, 5.56%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.56%
Neck Pain: 1 person, 5.56%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 1 person, 5.56%
Mania (a state of abnormally elevated or irritable mood): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Valproic acid (36,193 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,297 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,340 conditions)

Related publications that referenced our studies

Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.