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Valproic acid and Skin exfoliation - a phase IV clinical study of FDA data

Summary:

Skin exfoliation is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lamictal, and have Nuclear magnetic resonance imaging brain.

The phase IV clinical study analyzes which people have Skin exfoliation when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Skin exfoliation?

Skin exfoliation (removal of the oldest dead skin cells) is found to be associated with 1,734 drugs and 1,994 conditions by eHealthMe. Check the latest studies of Skin exfoliation.

On Aug, 11, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 34 people (0.09%) have Skin exfoliation.

Could Valproic acid cause Skin exfoliation?

Among these 34 people:

How long have people been on Valproic acid when they have Skin exfoliation? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Skin exfoliation when taking Valproic acid? *

  • female: 63.64 %
  • male: 36.36 %

What is the age of people who have Skin exfoliation when taking Valproic acid? *

  • 0-1: 0.0 %
  • 2-9: 3.57 %
  • 10-19: 7.14 %
  • 20-29: 14.29 %
  • 30-39: 10.71 %
  • 40-49: 21.43 %
  • 50-59: 17.86 %
  • 60+: 25.0 %

What are other drugs people take besides Valproic acid? *

  1. Lisinopril: 4 people, 11.76%
  2. Phenytoin: 4 people, 11.76%
  3. Tegretol: 4 people, 11.76%
  4. Keppra: 4 people, 11.76%
  5. Lamictal: 4 people, 11.76%
  6. Optimark: 3 people, 8.82%
  7. Cytoxan: 3 people, 8.82%
  8. Clonidine: 3 people, 8.82%
  9. Morphine: 3 people, 8.82%
  10. Dilantin: 3 people, 8.82%

What are other side effects people have besides Skin exfoliation? *

  1. Rashes (redness): 17 people, 50.00%
  2. Erythema Multiforme (a type of hypersensitivity reaction): 13 people, 38.24%
  3. Fever: 11 people, 32.35%
  4. Oedema Peripheral (superficial swelling): 11 people, 32.35%
  5. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 9 people, 26.47%
  6. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 7 people, 20.59%
  7. Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 7 people, 20.59%
  8. Itching: 5 people, 14.71%
  9. Skin Burning Sensation: 4 people, 11.76%
  10. Nikolsky's Sign: 4 people, 11.76%

What are the existing conditions these people have? *

  1. Nuclear Magnetic Resonance Imaging Brain: 3 people, 8.82%
  2. Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.88%
  3. Soft Tissue Infection: 1 person, 2.94%
  4. Headache (pain in head): 1 person, 2.94%
  5. Aggression: 1 person, 2.94%
  6. Breast Cancer Stage Iv: 1 person, 2.94%
  7. Cellulitis (infection under the skin): 1 person, 2.94%
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 2.94%
  9. Delusion (a false belief or opinion): 1 person, 2.94%
  10. Depression: 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Skin exfoliation?

- Check whether Skin exfoliation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Skin exfoliation treatments and more:

How severe was Skin exfoliation and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin exfoliation:

Browse all the conditions that are associated with Skin exfoliation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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