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Valproic acid and Type 1 diabetes - a phase IV clinical study of FDA data

Summary:

Type 1 diabetes is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are male, 10-19 old, also take Seroquel, and have Autism spectrum disorder.

The phase IV clinical study analyzes which people have Type 1 diabetes when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Type 1 diabetes?

Type 1 diabetes is found to be associated with 668 drugs and 1,644 conditions by eHealthMe. Check the latest studies of Type 1 diabetes.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 48 people (0.13%) have Type 1 diabetes.

Could Valproic acid cause Type 1 diabetes?

Among these 48 people:

What is the gender of people who have Type 1 diabetes when taking Valproic acid? *

  • female: 23.08 %
  • male: 76.92 %

What is the age of people who have Type 1 diabetes when taking Valproic acid? *

  • 0-1: 0.0 %
  • 2-9: 3.03 %
  • 10-19: 39.39 %
  • 20-29: 24.24 %
  • 30-39: 18.18 %
  • 40-49: 6.06 %
  • 50-59: 3.03 %
  • 60+: 6.06 %

What are other drugs people take besides Valproic acid? *

  1. Seroquel: 8 people, 16.67%
  2. Ativan: 6 people, 12.50%
  3. Depakote: 5 people, 10.42%
  4. Celexa: 4 people, 8.33%
  5. Paxil: 4 people, 8.33%
  6. Naproxen: 4 people, 8.33%
  7. Geodon: 4 people, 8.33%
  8. Haldol: 4 people, 8.33%
  9. Zyprexa: 3 people, 6.25%
  10. Risperdal: 3 people, 6.25%

What are other side effects people have besides Type 1 diabetes? *

  1. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 10 people, 20.83%
  2. Drug Ineffective: 10 people, 20.83%
  3. Diabetic Hyperosmolar Coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration)): 10 people, 20.83%
  4. Blood Glucose Increased: 10 people, 20.83%
  5. Streptococcal Sepsis (whole body inflammation by streptococcal): 9 people, 18.75%
  6. Weight Increased: 8 people, 16.67%
  7. Urination - Excessive Volume: 8 people, 16.67%
  8. Thirst - Excessive: 8 people, 16.67%
  9. Glycosylated Haemoglobin Increased: 8 people, 16.67%
  10. Diabetes: 8 people, 16.67%

What are the existing conditions these people have? *

  1. Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 13 people, 27.08%
  2. Aggression: 12 people, 25.00%
  3. Psychiatric Symptom: 7 people, 14.58%
  4. Depression: 5 people, 10.42%
  5. Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 5 people, 10.42%
  6. Sleep Disorder: 4 people, 8.33%
  7. Affective Disorder (mental disorder): 4 people, 8.33%
  8. Diabetes: 4 people, 8.33%
  9. Insomnia (sleeplessness): 3 people, 6.25%
  10. Hallucination, Auditory (perceiving sounds without auditory stimulus): 2 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Type 1 diabetes?

- Check whether Type 1 diabetes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Type 1 diabetes treatments and more:

How severe was Type 1 diabetes and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Type 1 diabetes:

Browse all the conditions that are associated with Type 1 diabetes:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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