Varenicline tartrate and Musculoskeletal stiffness - a phase IV clinical study of FDA data

Summary:

Musculoskeletal stiffness is reported as a side effect among people who take Varenicline tartrate (varenicline tartrate), especially for people who are female, 40-49 old, also take Synthroid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Musculoskeletal stiffness when taking Varenicline tartrate. It is created by eHealthMe based on reports of 3,776 people who have side effects when taking Varenicline tartrate from the FDA, and is updated regularly.

What is Varenicline tartrate?

Varenicline tartrate has active ingredients of varenicline tartrate. eHealthMe is studying from 3,777 Varenicline tartrate users. Check the latest studies of Varenicline tartrate.

What is Musculoskeletal stiffness?

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) is found to be associated with 1,960 drugs and 1,916 conditions by eHealthMe. Check the latest studies of Musculoskeletal stiffness.

On Jul, 09, 2026

3,776 people reported to have side effects when taking Varenicline tartrate.
Among them, 24 people (0.64%) have Musculoskeletal stiffness.

Could Varenicline tartrate cause Musculoskeletal stiffness?

Among these 24 people:

What is the gender of people who have Musculoskeletal stiffness when taking Varenicline tartrate? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Musculoskeletal stiffness when taking Varenicline tartrate? *

What are other drugs people take besides Varenicline tartrate? *

What are other side effects people have besides Musculoskeletal stiffness? *

Joint Swelling: 14 people, 58.33%
Nausea (feeling of having an urge to vomit): 14 people, 58.33%
Pain: 13 people, 54.17%
Joint Pain: 13 people, 54.17%
Rashes (redness): 12 people, 50.00%
Hypersensitivity: 11 people, 45.83%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 33.33%
Diarrhea: 8 people, 33.33%
Nausea And Vomiting: 8 people, 33.33%
Retinal Toxicity (retina damage due to medication): 8 people, 33.33%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 16 people, 66.67%
Hypersensitivity: 7 people, 29.17%
Quit Smoking: 4 people, 16.67%
Migraine (headache): 4 people, 16.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 12.50%
High Blood Pressure: 2 people, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Varenicline tartrate and have Musculoskeletal stiffness?

- Check whether Musculoskeletal stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Varenicline tartrate:

Varenicline tartrate (3,777 reports)

Browse all side effects of Varenicline tartrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,960 drugs)

Browse all the conditions that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,916 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on varenicline tartrate (the active ingredients of Varenicline tartrate) and Varenicline tartrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.