Vfend and Hepatocellular damage - a phase IV clinical study of FDA data

Summary:

Hepatocellular damage is reported as a side effect among people who take Vfend (voriconazole), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Hepatocellular damage when taking Vfend. It is created by eHealthMe based on reports of 12,081 people who have side effects when taking Vfend from the FDA, and is updated regularly.

What is Vfend?

Vfend has active ingredients of voriconazole. It is often used in aspergillosis. eHealthMe is studying from 12,128 Vfend users. Check the latest studies of Vfend.

What is Hepatocellular damage?

Hepatocellular damage (liver damage) is found to be associated with 503 drugs and 610 conditions by eHealthMe. Check the latest studies of Hepatocellular damage.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12,081 people reported to have side effects when taking Vfend.
Among them, 20 people (0.17%) have Hepatocellular damage.

Could Vfend cause Hepatocellular damage?

Among these 20 people:

How long have people been on Vfend when they have Hepatocellular damage? *

What is the gender of people who have Hepatocellular damage when taking Vfend? *

female: 42.11 %
male: 57.89 %

What is the age of people who have Hepatocellular damage when taking Vfend? *

What are other drugs people take besides Vfend? *

What are other side effects people have besides Hepatocellular damage? *

Acute Kidney Failure: 8 people, 40.00%
Hepatic Failure (liver failure): 6 people, 30.00%
Hepatotoxicity (chemical-driven liver damage): 6 people, 30.00%
Multi-Organ Failure (multisystem organ failure): 6 people, 30.00%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 6 people, 30.00%
Pneumonia: 6 people, 30.00%
Cardiac Failure: 5 people, 25.00%
Coma Hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma): 5 people, 25.00%
Hepatomegaly (abnormal enlargement of the liver): 4 people, 20.00%
High Blood Pressure: 4 people, 20.00%

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 20.00%
Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 3 people, 15.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 10.00%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 2 people, 10.00%
Candida Sepsis (candida in blood stream): 2 people, 10.00%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 1 person, 5.00%
Pneumonia Aspergillus (invasive type is a serious infection with pneumonia that can spread to other parts of the body): 1 person, 5.00%
Intervertebral Discitis (infection in the intervertebral disc space): 1 person, 5.00%
Febrile Neutropenia (fever with reduced white blood cells): 1 person, 5.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Vfend and have Hepatocellular damage?

- Check whether Hepatocellular damage is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vfend:

Vfend (12,128 reports)

Browse all side effects of Vfend:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatocellular damage:

Hepatocellular damage (503 drugs)

Browse all the conditions that are associated with Hepatocellular damage:

Hepatocellular damage (610 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on voriconazole (the active ingredients of Vfend) and Vfend (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.