Viagra and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Viagra (sildenafil citrate), especially for people who are male, 40-49 old, also take Lipitor, and have Pain.

The phase IV clinical study analyzes which people have Major depression when taking Viagra. It is created by eHealthMe based on reports of 61,803 people who have side effects when taking Viagra from the FDA, and is updated regularly.

What is Viagra?

Viagra has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 63,865 Viagra users. Check the latest studies of Viagra.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 803 drugs and 1,476 conditions by eHealthMe. Check the latest studies of Major depression.

On Jul, 20, 2026

61,803 people reported to have side effects when taking Viagra.
Among them, 26 people (0.04%) have Major depression.

Among these 26 people:

What is the gender of people who have Major depression when taking Viagra? *

female: 0.0 %
male: 100 %

What is the age of people who have Major depression when taking Viagra? *

What are other drugs people take besides Viagra? *

What are other side effects people have besides Major depression? *

Headache (pain in head): 11 people, 42.31%
Weight Decreased: 10 people, 38.46%
Insomnia (sleeplessness): 10 people, 38.46%
Dyspnea (difficult or laboured breathing): 9 people, 34.62%
Osteomyelitis (infection of bone): 9 people, 34.62%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 9 people, 34.62%
Rashes (redness): 9 people, 34.62%
Bone Disorder: 9 people, 34.62%
Pain In Jaw: 9 people, 34.62%
Stress And Anxiety: 7 people, 26.92%

What are the existing conditions these people have? *

Pain: 7 people, 26.92%
High Blood Pressure: 5 people, 19.23%
High Blood Cholesterol: 4 people, 15.38%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 11.54%
Multiple Myeloma (cancer of the plasma cells): 3 people, 11.54%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 11.54%
Parkinson's Disease: 2 people, 7.69%
Muscle Rigidity (muscle stiffness): 2 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%
Blood Pressure Abnormal: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Viagra and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Viagra:

Viagra (63,865 reports)

Major depression treatments and more:

Major depression (44,979 reports)

Browse all side effects of Viagra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (803 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,476 conditions)

Related publications that referenced our studies

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on sildenafil citrate (the active ingredients of Viagra) and Viagra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.