Vicodin and Hyperchlorhydria - a phase IV clinical study of FDA data

Summary:

Hyperchlorhydria is reported as a side effect among people who take Vicodin (acetaminophen; hydrocodone bitartrate), especially for people who are male, 40-49 old, have been taking the drug for 5 - 10 years also take Wellbutrin, and have Depression.

The phase IV clinical study analyzes which people have Hyperchlorhydria when taking Vicodin. It is created by eHealthMe based on reports of 59,416 people who have side effects when taking Vicodin from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Hyperchlorhydria?

Hyperchlorhydria (gastric acid levels are higher in stomach) is found to be associated with 389 drugs and 479 conditions by eHealthMe. Check the latest studies of Hyperchlorhydria.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

59,416 people reported to have side effects when taking Vicodin.
Among them, 13 people (0.02%) have Hyperchlorhydria.

Among these 13 people:

How long have people been on Vicodin when they have Hyperchlorhydria? *

What is the gender of people who have Hyperchlorhydria when taking Vicodin? *

female: 25 %
male: 75 %

What is the age of people who have Hyperchlorhydria when taking Vicodin? *

What are other drugs people take besides Vicodin? *

What are other side effects people have besides Hyperchlorhydria? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 61.54%
Insomnia (sleeplessness): 5 people, 38.46%
Chest Pain: 5 people, 38.46%
Dizziness: 4 people, 30.77%
Erection Problems: 4 people, 30.77%
Fatigue (feeling of tiredness): 4 people, 30.77%
Cough: 4 people, 30.77%
Cataract (clouding of the lens inside the eye): 4 people, 30.77%
Infection: 4 people, 30.77%
Stable Angina (a constant chest pain): 4 people, 30.77%

What are the existing conditions these people have? *

Depression: 3 people, 23.08%
Bipolar Disorder (mood disorder): 2 people, 15.38%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 2 people, 15.38%
Thyroid Diseases: 1 person, 7.69%
Hepatitis C: 1 person, 7.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.69%
Cough: 1 person, 7.69%
Eye Haemorrhage (bleeding in the eye): 1 person, 7.69%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 7.69%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Vicodin and have Hyperchlorhydria?

- Check whether Hyperchlorhydria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vicodin:

Vicodin (63,357 reports)

Hyperchlorhydria treatments and more:

Hyperchlorhydria (52,226 reports)

How severe was Hyperchlorhydria and when was it recovered:

Hyperchlorhydria in Vicodin

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Hyperchlorhydria and drugs with ingredients of acetaminophen; hydrocodone bitartrate (57 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperchlorhydria:

Hyperchlorhydria (389 drugs)

Browse all the conditions that are associated with Hyperchlorhydria:

Hyperchlorhydria (479 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Vicodin) and Vicodin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.