Vicodin and Synovitis - a phase IV clinical study of FDA data

Summary:

Synovitis is reported as a side effect among people who take Vicodin (acetaminophen; hydrocodone bitartrate), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Aredia, and have Metastases to bone.

The phase IV clinical study analyzes which people have Synovitis when taking Vicodin. It is created by eHealthMe based on reports of 59,416 people who have side effects when taking Vicodin from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Synovitis?

Synovitis (inflammation of the synovial membrane) is found to be associated with 695 drugs and 508 conditions by eHealthMe. Check the latest studies of Synovitis.

On Jul, 07, 2026

59,416 people reported to have side effects when taking Vicodin.
Among them, 72 people (0.12%) have Synovitis.

Among these 72 people:

How long have people been on Vicodin when they have Synovitis? *

What is the gender of people who have Synovitis when taking Vicodin? *

female: 75.71 %
male: 24.29 %

What is the age of people who have Synovitis when taking Vicodin? *

What are other drugs people take besides Vicodin? *

What are other side effects people have besides Synovitis? *

Joint Pain: 51 people, 70.83%
Stress And Anxiety: 50 people, 69.44%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 46 people, 63.89%
Osteonecrosis Of Jaw (death of bone of jaw): 37 people, 51.39%
Fever: 36 people, 50.00%
Spinal Osteoarthritis (joint cartilage loss in spine): 34 people, 47.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 31 people, 43.06%
Chest Pain: 31 people, 43.06%
Diarrhea: 31 people, 43.06%
Weight Decreased: 31 people, 43.06%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 20 people, 27.78%
Breast Cancer: 11 people, 15.28%
Stress And Anxiety: 9 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 9.72%
Glaucoma (increased fluid pressure in the eye with vision loss): 6 people, 8.33%
Osteoporosis (bones weak and more likely to break): 6 people, 8.33%
Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 5 people, 6.94%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 6.94%
Depression: 4 people, 5.56%
Insomnia (sleeplessness): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Vicodin and have Synovitis?

- Check whether Synovitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vicodin:

Vicodin (63,357 reports)

Synovitis treatments and more:

Synovitis (24,130 reports)

How severe was Synovitis and when was it recovered:

Synovitis in Vicodin

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Synovitis and drugs with ingredients of acetaminophen; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Synovitis:

Synovitis (695 drugs)

Browse all the conditions that are associated with Synovitis:

Synovitis (508 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Vicodin) and Vicodin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.